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Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

de Brito Alves, José L ; de Oliveira, Jéssica M D ; Ferreira, Diorginis J S ; Barros, Monique A de V ; Nogueira, Viviane O ; Alves, Débora S ; Vidal, Hubert ; Leandro, Carol G ; Lagranha, Cláudia J ; Pirola, Luciano ; da Costa-Silva, João H

Clinical and experimental pharmacology & physiology, 2016-12, Vol.43 (12), p.1177-1184 [Periódico revisado por pares]

Australia: Blackwell Publishing Ltd

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Título:
Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata
Autor: de Brito Alves, José L ; de Oliveira, Jéssica M D ; Ferreira, Diorginis J S ; Barros, Monique A de V ; Nogueira, Viviane O ; Alves, Débora S ; Vidal, Hubert ; Leandro, Carol G ; Lagranha, Cláudia J ; Pirola, Luciano ; da Costa-Silva, João H
Assuntos: Animals ; Diet, Protein-Restricted - adverse effects ; Female ; hypertension ; Hypertension - etiology ; Hypertension - metabolism ; Life Sciences ; Male ; Maternal Exposure - adverse effects ; medulla ; Medulla Oblongata - metabolism ; oxidative status ; Oxidative Stress - physiology ; Pregnancy ; Prenatal Exposure Delayed Effects - etiology ; Prenatal Exposure Delayed Effects - metabolism ; protein restriction ; Random Allocation ; Rats ; Rats, Wistar ; sympathetic overactivity ; Transcription, Genetic - physiology
É parte de: Clinical and experimental pharmacology & physiology, 2016-12, Vol.43 (12), p.1177-1184
Notas: ark:/67375/WNG-C6D1LRV8-F
CAPES/COFECUB - No. 797-14
istex:798EE857DE888C4F0E82191BE57DB47298B0C827
National Council of Technological and Scientific Development; CNPQ - No. 484452/2011-8; No. 478640/2013-7; No. 459341/2014-6
ArticleID:CEP12667
Pernambuco Research Foundation - No. 1365-2.07/10; No. 0765-4.05/10; No. PRONEM-0797-4.05/14
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Summary Maternal protein restriction during pregnancy and lactation predisposes the adult offspring to sympathetic overactivity and arterial hypertension. Although the underlying mechanisms are poorly understood, dysregulation of the oxidative balance has been proposed as a putative trigger of neural‐induced hypertension. The aim of the study was to evaluate the association between the oxidative status at transcriptional and functional levels in the medulla oblongata and maternal protein restriction induced‐hypertension. Wistar rat dams were fed a control (normal protein; 17% protein) or a low protein ((Lp); 8% protein) diet during pregnancy and lactation, and male offspring was studied at 90 days of age. Direct measurements of baseline arterial blood pressure (ABP) and heart rate (HR) were recorded in awakened offspring. In addition, quantitative RT‐PCR was used to assess the mRNA expression of superoxide dismutase 1 (SOD1) and 2 (SOD2), catalase (CAT), glutathione peroxidase (GPx), Glutamatergic receptors (Grin1, Gria1 and Grm1) and GABA(A)‐receptor‐associated protein like 1 (Gabarapl1). Malondialdehyde (MDA) levels, CAT and SOD activities were examined in ventral and dorsal medulla. Lp rats exhibited higher ABP. The mRNA expression levels of SOD2, GPx and Gabarapl1 were down regulated in medullary tissue of Lp rats (P<.05, t test). In addition, we observed that higher MDA levels were associated to decreased SOD (approximately 45%) and CAT (approximately 50%) activities in ventral medulla. Taken together, our data suggest that maternal protein restriction induced‐hypertension is associated with medullary oxidative dysfunction at transcriptional level and with impaired antioxidant capacity in the ventral medulla.
Editor: Australia: Blackwell Publishing Ltd
Idioma: Inglês

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Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

de Brito Alves, José L ; de Oliveira, Jéssica M D ; Ferreira, Diorginis J S ; Barros, Monique A de V ; Nogueira, Viviane O ; Alves, Débora S ; Vidal, Hubert ; Leandro, Carol G ; Lagranha, Cláudia J ; Pirola, Luciano ; da Costa-Silva, João H

Australia: Blackwell Publishing Ltd

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