Idioma:

Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study

de Vries, Elisabeth M. G. ; de Krijger, Manon ; Färkkilä, Martti ; Arola, Johanna ; Schirmacher, Peter ; Gotthardt, Daniel ; Goeppert, Benjamin ; Trivedi, Palak J. ; Hirschfield, Gideon M. ; Ytting, Henriette ; Vainer, Ben ; Buuren, Henk R. van ; Biermann, Katharina ; Harms, Maren H. ; Chazouilleres, Olivier ; Wendum, Dominique ; Kemgang, Astrid D. ; Chapman, Roger W. ; Wang, Lai Mun ; Williamson, Kate D. ; Gouw, Annette S. H. ; Paradis, Valerie ; Sempoux, Christine ; Beuers, Ulrich ; Hübscher, Stefan G. ; Verheij, Joanne ; Ponsioen, Cyriel Y.

Hepatology (Baltimore, Md.), 2017-03, Vol.65 (3), p.907-919 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study
Autor: de Vries, Elisabeth M. G. ; de Krijger, Manon ; Färkkilä, Martti ; Arola, Johanna ; Schirmacher, Peter ; Gotthardt, Daniel ; Goeppert, Benjamin ; Trivedi, Palak J. ; Hirschfield, Gideon M. ; Ytting, Henriette ; Vainer, Ben ; Buuren, Henk R. van ; Biermann, Katharina ; Harms, Maren H. ; Chazouilleres, Olivier ; Wendum, Dominique ; Kemgang, Astrid D. ; Chapman, Roger W. ; Wang, Lai Mun ; Williamson, Kate D. ; Gouw, Annette S. H. ; Paradis, Valerie ; Sempoux, Christine ; Beuers, Ulrich ; Hübscher, Stefan G. ; Verheij, Joanne ; Ponsioen, Cyriel Y.
Assuntos: Adult ; Biopsy ; Biopsy, Needle ; Cholangitis, Sclerosing - mortality ; Cholangitis, Sclerosing - pathology ; Cholangitis, Sclerosing - surgery ; Cohort Studies ; Female ; Hepatology ; Humans ; Immunohistochemistry ; Internationality ; Kaplan-Meier Estimate ; Life Sciences ; Liver ; Liver Transplantation - methods ; Liver Transplantation - mortality ; Male ; Middle Aged ; Multivariate Analysis ; Observer Variation ; Prognosis ; Proportional Hazards Models ; Risk Assessment ; Severity of Illness Index ; Survival Rate ; Treatment Outcome
É parte de: Hepatology (Baltimore, Md.), 2017-03, Vol.65 (3), p.907-919
Notas: This paper presents independent research; as such, the views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health.
Potential conflict of interest: Dr. Ponsioen advises and has received grants from Takeda and AbbVie.
Correction added on February 7, 2017, after first online publication: new affiliations 13 and 14 were added and the rest renumbered, resulting in a change in affiliation number for authors Lai Mun Wang, Annette S.H. Gouw, Valerie Paradis, Christine Sempoux, Stefan J. Hübscher, and Joanne Verheij.
P.J.T. received funding from a Wellcome Trust Clinical Research Fellowship. P.J.T. and G.M.H. are supported by the National Institute for Health Research Birmingham Liver Biomedical Research Unit.
Shared senior authors.
Contributed equally to this study.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Histologic scoring systems specific for primary sclerosing cholangitis (PSC) are not validated. We recently determined the applicability and prognostic value of three histological scoring systems in a single PSC cohort. The aim of this study was to validate their prognostic use and reproducibility across a multicenter PSC cohort. Liver biopsies from PSC patients were collected from seven European institutions. Histologic scoring was performed using the Nakanuma, Ishak, and Ludwig scoring systems. Biopsies were independently scored by six liver pathologists for interobserver agreement. The prognostic value of clinical, biochemical, and all three histologic scoring systems on predicting composite endpoints 1 (PSC‐related death and liver transplantation), 2 (liver transplantation), and 3 (liver‐related events), was assessed using univariable and multivariable Cox proportional hazards modeling. A total of 119 PSC patients were identified, and the median follow‐up was 142 months. During follow‐up, 31 patients died (20 PSC‐related deaths), 31 patients underwent liver transplantation, and 35 patients experienced one or more liver‐related events. All three staging systems were independent predictors of endpoints 2 and 3 (Nakanuma system: hazard ratio [HR], 3.16 [95% confidence interval (CI), 1.49‐6.68] for endpoint 2 and HR, 2.05 [95% CI, 1.17‐3.57] for endpoint 3; Ishak system: HR, 1.55 [95% CI, 1.10‐2.18] for endpoint 2 and HR, 1.43 [95% CI, 1.10‐1.85] for endpoint 3; Ludwig system: HR, 2.62 [95% CI, 1.19‐5.80] for endpoint 2 and HR, 2.06 [95% CI, 1.09‐3.89] for endpoint 3). Only the Nakanuma staging system was independently associated with endpoint 1: HR, 2.14 (95% CI, 1.22‐3.77). Interobserver agreement was moderate for Nakanuma stage (κ = 0.56) and substantial for Nakanuma component fibrosis (κ = 0.67), Ishak stage (κ = 0.64), and Ludwig stage (κ = 0.62). Conclusion: We confirm the independent prognostic value and demonstrate for the first time the reproducibility of staging disease progression in PSC using the Nakanuma, Ishak, and Ludwig staging systems. The Nakanuma staging system—incorporating features of chronic biliary disease—again showed the strongest predictive value. (Hepatology 2017;65:907‐919).
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study

United States: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.