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Spatiotemporal source analysis in scalp EEG vs. intracerebral EEG and SPECT: A case study in a 2-year-old child

Aarabi, A ; Grebe, R ; Berquin, P ; Bourel Ponchel, E ; Jalin, C ; Fohlen, M ; Bulteau, C ; Delalande, O ; Gondry, C ; Héberlé, C ; Moullart, V ; Wallois, F

Neurophysiologie clinique, 2012-06, Vol.42 (4), p.207-224 [Periódico revisado por pares]

Paris: Elsevier SAS

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Título:
Spatiotemporal source analysis in scalp EEG vs. intracerebral EEG and SPECT: A case study in a 2-year-old child
Autor: Aarabi, A ; Grebe, R ; Berquin, P ; Bourel Ponchel, E ; Jalin, C ; Fohlen, M ; Bulteau, C ; Delalande, O ; Gondry, C ; Héberlé, C ; Moullart, V ; Wallois, F
Assuntos: Biological and medical sciences ; Brain Mapping ; Child, Preschool ; Children ; Chirurgie de l’épilepsie ; Classification spatiotemporelle ; Classification temporospatiale ; Cognitive science ; Computed tomography ; Crise épileptique ; Dipole modeling ; EEG ; EEG haute résolution ; Electrodes ; Electrodiagnosis. Electric activity recording ; Electroencephalography - methods ; Enfant ; Enregistrements intracérébraux ; Epilepsies, Partial - physiopathology ; Epilepsy ; Epilepsy surgery ; Female ; Head ; High-resolution EEG ; Humans ; Interictal spikes ; Intracerebral recordings ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Modélisation de dipôles ; Monitoring, Physiologic - methods ; Nervous system ; Neurology ; Neuroscience ; Pointes épileptiques intercritiques ; Presurgical evaluation ; Scalp ; Seizure ; Seizures ; Signal Processing, Computer-Assisted ; Single photon emission computed tomography ; spatial discrimination ; Spatiotemporal classification ; SPECT ; TEMP ; Tomography, Emission-Computed, Single-Photon - methods ; Évaluation préchirurgicale
É parte de: Neurophysiologie clinique, 2012-06, Vol.42 (4), p.207-224
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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Descrição: Summary Objective This case study aims to demonstrate that spatiotemporal spike discrimination and source analysis are effective to monitor the development of sources of epileptic activity in time and space. Therefore, they can provide clinically useful information allowing a better understanding of the pathophysiology of individual seizures with time- and space-resolved characteristics of successive epileptic states, including interictal, preictal, postictal, and ictal states. Methods High spatial resolution scalp EEGs (HR-EEG) were acquired from a 2-year-old girl with refractory central epilepsy and single-focus seizures as confirmed by intracerebral EEG recordings and ictal single-photon emission computed tomography (SPECT). Evaluation of HR-EEG consists of the following three global steps: (1) creation of the initial head model, (2) automatic spike and seizure detection, and finally (3) source localization. During the source localization phase, epileptic states are determined to allow state-based spike detection and localization of underlying sources for each spike. In a final cluster analysis, localization results are integrated to determine the possible sources of epileptic activity. The results were compared with the cerebral locations identified by intracerebral EEG recordings and SPECT. Results The results obtained with this approach were concordant with those of MRI, SPECT and distribution of intracerebral potentials. Dipole cluster centres found for spikes in interictal, preictal, ictal and postictal states were situated an average of 6.3 mm from the intracerebral contacts with the highest voltage. Both amplitude and shape of spikes change between states. Dispersion of the dipoles was higher in the preictal state than in the postictal state. Two clusters of spikes were identified. The centres of these clusters changed position periodically during the various epileptic states. Conclusion High-resolution surface EEG evaluated by an advanced algorithmic approach can be used to investigate the spatiotemporal characteristics of sources located in the epileptic focus. The results were validated by standard methods, ensuring good spatial resolution by MRI and SPECT and optimal temporal resolution by intracerebral EEG. Surface EEG can be used to identify different spike clusters and sources of the successive epileptic states. The method that was used in this study will provide physicians with a better understanding of the pathophysiological characteristics of epileptic activities. In particular, this method may be useful for more effective positioning of implantable intracerebral electrodes.
Editor: Paris: Elsevier SAS
Idioma: Inglês

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Spatiotemporal source analysis in scalp EEG vs. intracerebral EEG and SPECT: A case study in a 2-year-old child

Aarabi, A ; Grebe, R ; Berquin, P ; Bourel Ponchel, E ; Jalin, C ; Fohlen, M ; Bulteau, C ; Delalande, O ; Gondry, C ; Héberlé, C ; Moullart, V ; Wallois, F

Paris: Elsevier SAS

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