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Oxytocin enhances brain function in children with autism

Gordon, Ilanit ; Wyk, Brent C. Vander ; Bennett, Randi H. ; Cordeaux, Cara ; Lucas, Molly V. ; Eilbott, Jeffrey A. ; Zagoory-Sharon, Orna ; Leckman, James F. ; Feldman, Ruth ; Pelphrey, Kevin A.

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (52), p.20953-20958 [Periódico revisado por pares]

Washington, DC: National Academy of Sciences

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Título:
Oxytocin enhances brain function in children with autism
Autor: Gordon, Ilanit ; Wyk, Brent C. Vander ; Bennett, Randi H. ; Cordeaux, Cara ; Lucas, Molly V. ; Eilbott, Jeffrey A. ; Zagoory-Sharon, Orna ; Leckman, James F. ; Feldman, Ruth ; Pelphrey, Kevin A.
Assuntos: Administration, Intranasal ; Adolescent ; Amygdala ; Amygdala - drug effects ; Amygdala - metabolism ; Autism ; Autistic disorder ; Behavioral neuroscience ; Biological and medical sciences ; Brain ; Child ; Child clinical studies ; Child Development Disorders, Pervasive - drug therapy ; Children ; Children & youth ; Developmental disorders ; Female ; Frontal Lobe - drug effects ; Frontal Lobe - metabolism ; Humans ; Infantile autism ; Judgment ; Judgment - drug effects ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory ; NMR ; Nuclear magnetic resonance ; Oxytocin - administration & dosage ; Oxytocin - analysis ; Oxytocin - pharmacology ; Pervasive child development disorders ; Placebos ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Saliva - chemistry ; Social Adjustment ; Social behavior ; Social interaction ; Social Sciences ; Vehicles
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (52), p.20953-20958
Notas: http://dx.doi.org/10.1073/pnas.1312857110
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Author contributions: I.G., J.F.L., R.F., and K.A.P. designed research; I.G., R.H.B., C.C., and M.V.L. performed research; O.Z.-S. contributed new reagents/analytic tools; I.G., B.C.V.W., J.A.E., O.Z.-S., and K.A.P. analyzed data; I.G. and K.A.P. wrote the paper; and J.F.L. was the medical doctor in charge of the study.
Edited by Leslie G. Ungerleider, National Institute of Mental Health, Bethesda, MD, and approved November 6, 2013 (received for review July 8, 2013)
Descrição: Following intranasal administration of oxytocin (OT), we measured, via functional MRI, changes in brain activity during judgments of socially (Eyes) and nonsocially (Vehicles) meaningful pictures in 17 children with high-functioning autism spectrum disorder (ASD). OT increased activity in the striatum, the middle frontal gyrus, the medial prefrontal cortex, the right orbitofrontal cortex, and the left superior temporal sulcus. In the striatum, nucleus accumbens, left posterior superior temporal sulcus, and left premotor cortex, OT increased activity during social judgments and decreased activity during nonsocial judgments. Changes in salivary OT concentrations from baseline to 30 min postadministration were positively associated with increased activity in the right amygdala and orbitofrontal cortex during social vs. nonsocial judgments. OT may thus selectively have an impact on salience and hedonic evaluations of socially meaningful stimuli in children with ASD, and thereby facilitate social attunement. These findings further the development of a neurophysiological systems-level understanding of mechanisms by which OT may enhance social functioning in children with ASD.
Editor: Washington, DC: National Academy of Sciences
Idioma: Inglês

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Oxytocin enhances brain function in children with autism

Gordon, Ilanit ; Wyk, Brent C. Vander ; Bennett, Randi H. ; Cordeaux, Cara ; Lucas, Molly V. ; Eilbott, Jeffrey A. ; Zagoory-Sharon, Orna ; Leckman, James F. ; Feldman, Ruth ; Pelphrey, Kevin A.

Washington, DC: National Academy of Sciences

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