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The input pathways to the circadian clock: from nocturnality to diurnality

Schoonderwoerd, R.A.

2023

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  • Título:
    The input pathways to the circadian clock: from nocturnality to diurnality
  • Autor: Schoonderwoerd, R.A.
  • Assuntos: Circadian rhythms ; Diurnality ; Neurophysiology ; Suprachiasmatic nucleus
  • Descrição: Most organisms on Earth anticipate changes between day and night using an internal biological clock. This clock is localized in a small brain area: the suprachiasmatic nucleus (SCN). The SCN generates rhythms of approximately 24 hours (circadian) which are synchronized to light. We investigated how light signals reach the SCN and how the effects of light and behavioural activity on the SCN differ between diurnal and nocturnal species. In this thesis, we show that cone photoreceptors, involved in colour vision, contribute to the light responses of the circadian clock. As observed in fMRI experiments, the human SCN was also sensitive to different colours of light. Furthermore, the SCN of diurnal species was partly inhibited by light, whereas the SCN of nocturnal species was mostly excited. Finally, we observed that behavioural activity activates the SCN of diurnal species, whereas in nocturnal species the SCN is inhibited. We concluded that the input pathways to the circadian clock differ between diurnal and nocturnal species and hypothesize that these differences could contribute to the temporal activity profiles. Together, our findings facilitate the translation of circadian research from nocturnal laboratory animals to diurnal humans, for the benefit of biological rhythms and health in general.
  • Data de criação/publicação: 2023
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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