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Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study

Omer, Saad B ; Goodman, David ; Steinhoff, Mark C ; Rochat, Roger ; Klugman, Keith P ; Stoll, Barbara J ; Ramakrishnan, Usha Cooper, Ben S.

PLoS medicine, 2011-05, Vol.8 (5), p.e1000441-e1000441 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study
Autor: Omer, Saad B ; Goodman, David ; Steinhoff, Mark C ; Rochat, Roger ; Klugman, Keith P ; Stoll, Barbara J ; Ramakrishnan, Usha
Cooper, Ben S.
Assuntos: Adolescent ; Adult ; Babies ; Birth Weight ; Cohort Studies ; Complications and side effects ; Female ; Georgia - epidemiology ; Health aspects ; Humans ; Immunization ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Small for Gestational Age ; Infectious Diseases ; Influenza ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Odds Ratio ; Pediatrics and Child Health/Neonatology ; Pregnancy ; Pregnancy Outcome - epidemiology ; Pregnant women ; Premature birth ; Premature Birth - epidemiology ; Prevention ; Retrospective Studies ; Risk factors ; Vaccines ; Womens health ; Young Adult
É parte de: PLoS medicine, 2011-05, Vol.8 (5), p.e1000441-e1000441
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ICMJE criteria for authorship read and met: SBO DG MCS RR KPK BJS UR. Agree with the manuscript′s results and conclusions: SBO DG MCS RR KPK BJS UR. Designed the experiments/the study: SBO DG MCS. Collected data/did experiments for the study: SBO. Analyzed the data: SBO MCS KPK BJS. Wrote the first draft of the paper: SBO. Contributed to the writing of the paper: SBO DG MCS RR KPK BJS UR. Led the study as the principal investigator: SBO. SBO and DG had full access to the study data and SBO had final responsibility for the decision to submit for publication.
Descrição: Infections during pregnancy have the potential to adversely impact birth outcomes. We evaluated the association between receipt of inactivated influenza vaccine during pregnancy and prematurity and small for gestational age (SGA) births. We conducted a cohort analysis of surveillance data from the Georgia (United States) Pregnancy Risk Assessment Monitoring System. Among 4,326 live births between 1 June 2004 and 30 September 2006, maternal influenza vaccine information was available for 4,168 (96.3%). The primary intervention evaluated in this study was receipt of influenza vaccine during any trimester of pregnancy. The main outcome measures were prematurity (gestational age at birth <37 wk) and SGA (birth weight <10th percentile for gestational age). Infants who were born during the putative influenza season (1 October-31 May) and whose mothers were vaccinated against influenza during pregnancy were less likely to be premature compared to infants of unvaccinated mothers born in the same period (adjusted odds ratio [OR] = 0.60; 95% CI, 0.38-0.94). The magnitude of association between maternal influenza vaccine receipt and reduced likelihood of prematurity increased during the period of at least local influenza activity (adjusted OR = 0.44; 95% CI, 0.26-0.73) and was greatest during the widespread influenza activity period (adjusted OR = 0.28; 95% CI, 0.11-0.74). Compared with newborns of unvaccinated women, newborns of vaccinated mothers had 69% lower odds of being SGA (adjusted OR = 0.31; 95% CI, 0.13-0.75) during the period of widespread influenza activity. The adjusted and unadjusted ORs were not significant for the pre-influenza activity period. This study demonstrates an association between immunization with the inactivated influenza vaccine during pregnancy and reduced likelihood of prematurity during local, regional, and widespread influenza activity periods. However, no associations were found for the pre-influenza activity period. Moreover, during the period of widespread influenza activity there was an association between maternal receipt of influenza vaccine and reduced likelihood of SGA birth.
Editor: United States: Public Library of Science
Idioma: Inglês

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Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study

Omer, Saad B ; Goodman, David ; Steinhoff, Mark C ; Rochat, Roger ; Klugman, Keith P ; Stoll, Barbara J ; Ramakrishnan, Usha Cooper, Ben S.

United States: Public Library of Science

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