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Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival

Chen, Guangdi ; Cheng, Yabin ; Zhang, Zhizhong ; Martinka, Magdalena ; Li, Gang Borgmann, Kerstin

PloS one, 2011-02, Vol.6 (2), p.e17578-e17578 [Revista revisada por pares]

United States: Public Library of Science

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Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival
Autor: Chen, Guangdi ; Cheng, Yabin ; Zhang, Zhizhong ; Martinka, Magdalena ; Li, Gang
Borgmann, Kerstin
Materias: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Analysis ; Apoptosis ; Biology ; Biomarkers ; Biomarkers, Tumor - metabolism ; Cancer metastasis ; Cancer patients ; Cell cycle ; Cell growth ; Cell survival ; Chemotherapy ; Child ; Cohort Studies ; Correlation ; Cytoplasm - metabolism ; Dermatology ; Development and progression ; Diagnosis ; Disease Progression ; Enzymes ; F-box protein ; Female ; Gene Expression Regulation, Neoplastic ; Gene therapy ; Humans ; Immunohistochemistry ; Kinases ; Lesions ; Localization ; Lung cancer ; Male ; Medical prognosis ; Medical research ; Medicine ; Melanoma ; Melanoma - diagnosis ; Melanoma - metabolism ; Melanoma - mortality ; Metastases ; Metastasis ; Middle Aged ; Pathogenesis ; Patient outcomes ; Patients ; Proteins ; Regression analysis ; Regression models ; Regulators ; S-Phase Kinase-Associated Proteins - metabolism ; Skin cancer ; Skin Neoplasms - diagnosis ; Skin Neoplasms - metabolism ; Skin Neoplasms - mortality ; Skp2 protein ; Survival ; Survival Analysis ; Tissue Array Analysis ; Ubiquitin ; Up-Regulation ; Young Adult
Es parte de: PloS one, 2011-02, Vol.6 (2), p.e17578-e17578
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: GL GC. Performed the experiments: GC. Analyzed the data: GC YC ZZ MM GL. Contributed reagents/materials/analysis tools: GL. Wrote the paper: GC GL.
Descripción: S-phase kinase protein 2 (Skp2), an F-box protein, targets cell cycle regulators via ubiquitin-mediated degradation. Skp2 is frequently overexpressed in a variety of cancers and associated with patient survival. In melanoma, however, the prognostic significance of subcellular Skp2 expression remains controversial. To investigate the role of Skp2 in melanoma development, we constructed tissue microarrays and examined Skp2 expression in melanocytic lesions at different stages, including 30 normal nevi, 61 dysplastic nevi, 290 primary melanomas and 146 metastatic melanomas. The TMA was assessed for cytoplasmic and nuclear Skp2 expression by immunohistochemistry. The Kaplan-Meier method was used to evaluate the patient survival. The univariate and multivariate Cox regression models were performed to estimate the hazard ratios (HR) at five-year follow-up. Cytoplasmic but not nuclear Skp2 expression was gradually increased from normal nevi, dysplastic nevi, primary melanomas to metastatic melanomas. Cytoplasmic Skp2 expression correlated with AJCC stages (I vs II-IV, P<0.001), tumor thickness (≤2.00 vs >2.00 mm, P<0.001) and ulceration (P = 0.005). Increased cytoplasmic Skp2 expression was associated with a poor five-year disease-specific survival of patients with primary melanoma (P = 0.018) but not metastatic melanoma (P>0.05). This study demonstrates that cytoplasmic Skp2 plays an important role in melanoma pathogenesis and its expression correlates with patient survival. Our data indicate that cytoplasmic Skp2 may serve as a potential biomarker for melanoma progression and a therapeutic target for this disease.
Editor: United States: Public Library of Science
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Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival

Chen, Guangdi ; Cheng, Yabin ; Zhang, Zhizhong ; Martinka, Magdalena ; Li, Gang Borgmann, Kerstin

United States: Public Library of Science

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