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REVIGO summarizes and visualizes long lists of gene ontology terms

Supek, Fran ; Bošnjak, Matko ; Škunca, Nives ; Šmuc, Tomislav Gibas, Cynthia

PloS one, 2011-07, Vol.6 (7), p.e21800-e21800 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
REVIGO summarizes and visualizes long lists of gene ontology terms
Autor: Supek, Fran ; Bošnjak, Matko ; Škunca, Nives ; Šmuc, Tomislav
Gibas, Cynthia
Assuntos: Acids ; Algorithms ; Bioinformatics ; Biology ; Breast cancer ; Clouds ; Clustering ; Computational Biology - methods ; Computer Science ; Experiments ; Gene expression ; Gene Expression Regulation ; Genes ; Genomes ; Genomics ; Graphical representations ; Humans ; Internet ; Lists ; Molecular Sequence Annotation ; Multidimensional scaling ; Ontology ; Prokaryotes ; Researchers ; Semantics ; Servers ; Software ; Subdivisions ; Transcription Factors - genetics ; Transcription Factors - metabolism ; User-Computer Interface ; Visualization (Computer) ; Visualization (Computers)
É parte de: PloS one, 2011-07, Vol.6 (7), p.e21800-e21800
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: FS TS. Performed the experiments: FS MB. Analyzed the data: FS MB NS. Wrote the paper: FS NS.
Descrição: Outcomes of high-throughput biological experiments are typically interpreted by statistical testing for enriched gene functional categories defined by the Gene Ontology (GO). The resulting lists of GO terms may be large and highly redundant, and thus difficult to interpret.REVIGO is a Web server that summarizes long, unintelligible lists of GO terms by finding a representative subset of the terms using a simple clustering algorithm that relies on semantic similarity measures. Furthermore, REVIGO visualizes this non-redundant GO term set in multiple ways to assist in interpretation: multidimensional scaling and graph-based visualizations accurately render the subdivisions and the semantic relationships in the data, while treemaps and tag clouds are also offered as alternative views. REVIGO is freely available at http://revigo.irb.hr/.
Editor: United States: Public Library of Science
Idioma: Inglês

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REVIGO summarizes and visualizes long lists of gene ontology terms

Supek, Fran ; Bošnjak, Matko ; Škunca, Nives ; Šmuc, Tomislav Gibas, Cynthia

United States: Public Library of Science

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