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The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma

Abdelwahab, Mohammed G ; Fenton, Kathryn E ; Preul, Mark C ; Rho, Jong M ; Lynch, Andrew ; Stafford, Phillip ; Scheck, Adrienne C Canoll, Peter

PloS one, 2012-05, Vol.7 (5), p.e36197-e36197 [Periódico revisado por pares]

United States: Public Library of Science

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The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma
Autor: Abdelwahab, Mohammed G ; Fenton, Kathryn E ; Preul, Mark C ; Rho, Jong M ; Lynch, Andrew ; Stafford, Phillip ; Scheck, Adrienne C
Canoll, Peter
Assuntos: 3-Hydroxybutyric Acid - metabolism ; Adjuvants ; Animal models ; Animals ; Anticancer properties ; Biology ; Blood ; Blood Glucose - metabolism ; Bone cancer ; Brain ; Brain - metabolism ; Brain - pathology ; Brain cancer ; Brain research ; Brain tumors ; Cancer therapies ; Carbohydrate metabolism ; Carbohydrates ; Cell growth ; Cell survival ; Chemistry ; Combined Modality Therapy ; Convulsions & seizures ; Diet, Ketogenic ; Diets ; Disease Models, Animal ; Epilepsy ; Gene expression ; Glioma ; Glioma - diet therapy ; Glioma - radiotherapy ; High fat diet ; Homeostasis ; Hospitals ; Humans ; Implantation ; Kaplan-Meier Estimate ; Ketogenesis ; Ketone bodies ; Ketones ; Ketones - blood ; Ketosis ; Kinases ; Low carbohydrate diet ; Lung cancer ; Medical treatment ; Medicine ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mortality ; Neoplasm Transplantation ; Neuroimaging ; Neurological diseases ; Neurosurgery ; Nutrition research ; Oncology ; Pediatrics ; Pharmacology ; Physiological aspects ; Proteins ; Radiation ; Radiation (Physics) ; Radiation therapy ; Radiotherapy ; Studies ; Surgical implants ; Time Factors ; Tumor cells ; Tumors
É parte de: PloS one, 2012-05, Vol.7 (5), p.e36197-e36197
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Conceived and designed the experiments: MCP JMR AL ACS. Performed the experiments: MGA KEF. Analyzed the data: MGA KEF PS ACS. Contributed reagents/materials/analysis tools: AL PS ACS. Wrote the paper: MGA KEF MCP JMR AL PS ACS.
Current address: Departments of Pediatrics and Clinical Neurosciences, Alberta Children's Hospital, University of Calgary, Calgary, Canada
Descrição: The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that alters metabolism by increasing the level of ketone bodies in the blood. KetoCal® (KC) is a nutritionally complete, commercially available 4:1 (fat:carbohydrate+protein) ketogenic formula that is an effective non-pharmacologic treatment for the management of refractory pediatric epilepsy. Diet-induced ketosis causes changes to brain homeostasis that have potential for the treatment of other neurological diseases such as malignant gliomas. We used an intracranial bioluminescent mouse model of malignant glioma. Following implantation animals were maintained on standard diet (SD) or KC. The mice received 2×4 Gy of whole brain radiation and tumor growth was followed by in vivo imaging. Animals fed KC had elevated levels of β-hydroxybutyrate (p = 0.0173) and an increased median survival of approximately 5 days relative to animals maintained on SD. KC plus radiation treatment were more than additive, and in 9 of 11 irradiated animals maintained on KC the bioluminescent signal from the tumor cells diminished below the level of detection (p<0.0001). Animals were switched to SD 101 days after implantation and no signs of tumor recurrence were seen for over 200 days. KC significantly enhances the anti-tumor effect of radiation. This suggests that cellular metabolic alterations induced through KC may be useful as an adjuvant to the current standard of care for the treatment of human malignant gliomas.
Editor: United States: Public Library of Science
Idioma: Inglês

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The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma

Abdelwahab, Mohammed G ; Fenton, Kathryn E ; Preul, Mark C ; Rho, Jong M ; Lynch, Andrew ; Stafford, Phillip ; Scheck, Adrienne C Canoll, Peter

United States: Public Library of Science

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