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Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country

Madeira, Francilene B ; Silva, Antônio A ; Veloso, Helma F ; Goldani, Marcelo Z ; Kac, Gilberto ; Cardoso, Viviane C ; Bettiol, Heloisa ; Barbieri, Marco A Bacurau, Reury FP

PloS one, 2013-03, Vol.8 (3), p.e60673-e60673 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country
Autor: Madeira, Francilene B ; Silva, Antônio A ; Veloso, Helma F ; Goldani, Marcelo Z ; Kac, Gilberto ; Cardoso, Viviane C ; Bettiol, Heloisa ; Barbieri, Marco A
Bacurau, Reury FP
Assuntos: Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Adult ; Adults ; Analysis ; Biology ; Body fat ; Body mass ; Body Mass Index ; Body size ; Brazil - epidemiology ; Cholesterol ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Female ; Females ; Homeostasis ; Humans ; Hypoglycemic agents ; Income ; Insulin ; Insulin Resistance ; Insulin secretion ; Male ; Males ; Medical research ; Medicine ; Medicine, Experimental ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - metabolism ; Nutrition ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obesity - metabolism ; Personal income ; Population studies ; Secretion ; Sensitivity ; Sensitivity analysis ; Sex ; Skin ; Teenagers ; Type 2 diabetes ; Young Adult ; Young adults ; Youth
É parte de: PloS one, 2013-03, Vol.8 (3), p.e60673-e60673
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Review the manuscript for intellectual content: FBM AAS HFV MZG GK VCC HB MAB. Conceived and designed the experiments: AAS MAB HB. Analyzed the data: FBM AAS HFV. Contributed reagents/materials/analysis tools: AAS MZG GK HB MAB. Wrote the paper: FBM AAS HFV MZG GK VCC HB MAB.
Competing Interests: The authors have declared that no competing interest exists.
Descrição: This population-based birth cohort study examined whether normal weight obesity is associated with metabolic disorders in young adults in a middle-income country undergoing rapid nutrition transition. The sample involved 1,222 males and females from the 1978/79 Ribeirão Preto birth cohort, Brazil, aged 23-25 years. NWO was defined as body mass index (BMI) within the normal range (18.5-24.9 kg/m(2)) and the sum of subscapular and triceps skinfolds above the sex-specific 90th percentiles of the study sample. It was also defined as normal BMI and % BF (body fat) >23% in men and >30% in women. Insulin resistance (IR), insulin sensitivity and secretion were based on the Homeostasis Model Assessment (HOMA) model. In logistic models, after adjusting for age, sex and skin colour, NWO was significantly associated with Metabolic Syndrome (MS) according to the Joint Interim Statement (JIS) definition (Odds Ratio OR = 6.83; 95% Confidence Interval CI 2.84-16.47). NWO was also associated with HOMA2-IR (OR = 3.81; 95%CI 1.57-9.28), low insulin sensitivity (OR = 3.89; 95%CI 2.39-6.33), and high insulin secretion (OR = 2.17; 95%CI 1.24-3.80). Significant associations between NWO and some components of the MS were also detected: high waist circumference (OR = 8.46; 95%CI 5.09-14.04), low High Density Lipoprotein cholesterol (OR = 1.65; 95%CI 1.11-2.47) and high triglyceride levels (OR = 1.93; 95%CI 1.02-3.64). Most estimates changed little after further adjustment for early and adult life variables. NWO was associated with MS and IR, suggesting that clinical assessment of excess body fat in normal-BMI individuals should begin early in life even in middle-income countries.
Editor: United States: Public Library of Science
Idioma: Inglês

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Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country

Madeira, Francilene B ; Silva, Antônio A ; Veloso, Helma F ; Goldani, Marcelo Z ; Kac, Gilberto ; Cardoso, Viviane C ; Bettiol, Heloisa ; Barbieri, Marco A Bacurau, Reury FP

United States: Public Library of Science

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