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On the respiratory mechanics measured by forced oscillation technique in patients with systemic sclerosis

Miranda, Ingrid Almeida ; Dias Faria, Alvaro Camilo ; Lopes, Agnaldo José ; Jansen, José Manoel ; Lopes de Melo, Pedro Tschumperlin, Daniel J.

PloS one, 2013-04, Vol.8 (4), p.e61657 [Periódico revisado por pares]

United States: Public Library of Science

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On the respiratory mechanics measured by forced oscillation technique in patients with systemic sclerosis
Autor: Miranda, Ingrid Almeida ; Dias Faria, Alvaro Camilo ; Lopes, Agnaldo José ; Jansen, José Manoel ; Lopes de Melo, Pedro
Tschumperlin, Daniel J.
Assuntos: Abnormalities ; Adult ; Alveoli ; Anthropometry ; Area Under Curve ; Biology ; Care and treatment ; Complications ; Complications and side effects ; Diagnosis ; Diagnostic systems ; Electric Impedance ; Engineering ; Female ; Forced Expiratory Flow Rates - physiology ; Humans ; Hypertension ; Laboratories ; Lung - physiopathology ; Lung diseases ; Lung Volume Measurements ; Lungs ; Male ; Mechanical properties ; Medicine ; Methods ; Middle Aged ; Morbidity ; Patients ; Physics ; Reactance ; Reference Standards ; Respiration ; Respiratory Function Tests - methods ; Respiratory Mechanics - physiology ; Respiratory system ; Scleroderma ; Scleroderma (Disease) ; Scleroderma, Systemic - physiopathology ; Sensitivity and Specificity ; Spirometry ; Studies ; Systemic scleroderma ; Systemic sclerosis
É parte de: PloS one, 2013-04, Vol.8 (4), p.e61657
Notas: Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: AJL JMJ PLM. Performed the experiments: IAM ACDF. Analyzed the data: IAM ACDF AJL JMJ PLM. Interpreted the data: IAM ACDF AJL JMJ PLM. Wrote the article or critical review: IAM ACDF AJL JMJ PLM. Concieved and organized the illustrations: IAM ACDF PLM. Final approval of the version for publication: IAM ACDF AJL JMJ PLM.
Descrição: Pulmonary complications are the most common cause of death and morbidity in systemic sclerosis (SSc). The forced oscillation technique (FOT) offers a simple and detailed approach to investigate the mechanical properties of the respiratory system. We hypothesized that SSc may introduce changes in the resistive and reactive properties of the respiratory system, and that FOT may help the diagnosis of these abnormalities. We tested these hypotheses in controls (n = 30) and patients with abnormalities classified using spirometry (n = 52) and pulmonary volumes (n = 29). Resistive data were interpreted with the zero-intercept resistance (Ri) and the slope of the resistance (S) as a function of frequency. Reactance changes were evaluated by the mean reactance between 4 and 32 Hz (Xm) and the dynamic compliance (Crs,dyn). The mechanical load was evaluated using the absolute value of the impedance in 4 Hz (Z4Hz). A compartmental model was used to obtain central (R) and peripheral (Rp) resistances, and alveolar compliance (C). The clinical usefulness was evaluated by investigating the area under the receiver operating characteristic curve (AUC). The presence of expiratory flow limitation (EFL) was also evaluated. For the groups classified using spirometry, SSc resulted in increased values in Ri, R, Rp and Z4Hz (p<0.003) and reductions in Crs,dyn, C and Xm (p<0.004). Z4Hz, C and Crs,dyn exhibited a high diagnostic accuracy (AUC>0.90). In groups classified by pulmonary volume, SSc resulted in reductions in S, Xm, C and Crs,dyn (p<0.01). Xm, C and Crs,dyn exhibited adequate diagnostic accuracy (AUC>0.80). It was also observed that EFL is not common in patients with SSc. This study provides evidence that the respiratory resistance and reactance are changed in SSc. This analysis provides a useful description that is of particular significance for understanding respiratory pathophysiology and to ease the diagnosis of respiratory abnormalities in these patients.
Editor: United States: Public Library of Science
Idioma: Inglês

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On the respiratory mechanics measured by forced oscillation technique in patients with systemic sclerosis

Miranda, Ingrid Almeida ; Dias Faria, Alvaro Camilo ; Lopes, Agnaldo José ; Jansen, José Manoel ; Lopes de Melo, Pedro Tschumperlin, Daniel J.

United States: Public Library of Science

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