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Alcohol drinking cessation and the risk of laryngeal and pharyngeal cancers: a systematic review and meta-analysis

Ahmad Kiadaliri, Aliasghar ; Jarl, Johan ; Gavriilidis, Georgios ; Gerdtham, Ulf-G Timmer, Antje

PloS one, 2013-03, Vol.8 (3), p.e58158 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Alcohol drinking cessation and the risk of laryngeal and pharyngeal cancers: a systematic review and meta-analysis
Autor: Ahmad Kiadaliri, Aliasghar ; Jarl, Johan ; Gavriilidis, Georgios ; Gerdtham, Ulf-G
Timmer, Antje
Assuntos: Adult ; Aged ; Aged, 80 and over ; Alcohol ; Alcohol Drinking - adverse effects ; Alcohol use ; Alcoholic beverages ; Arbetsmedicin och miljömedicin ; Carcinoma, Squamous Cell - etiology ; Complications and side effects ; Development and progression ; Drinking ; Drinking (Alcoholic beverages) ; Drinking behavior ; Drinking of alcoholic beverages ; Environmental Health and Occupational Health ; Ethanol - adverse effects ; Female ; Genetic aspects ; Head & neck cancer ; Head and Neck Neoplasms - etiology ; Health Care Service and Management, Health Policy and Services and Health Economy ; Health economics ; Health risks ; Health Sciences ; Hospitals ; Humans ; Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi ; Hälsovetenskap ; Laryngeal cancer ; Laryngeal Neoplasms - etiology ; Larynx ; Least squares method ; Least-Squares Analysis ; Literature reviews ; Male ; Medical and Health Sciences ; Medical ethics ; Medicin och hälsovetenskap ; Medicine ; Meta-analysis ; Middle Aged ; Pharyngeal cancer ; Pharyngeal Neoplasms - etiology ; Pharynx ; Reduction ; Risk ; Risk reduction ; Risk Reduction Behavior ; Smoking ; Social and Behavioral Sciences ; Squamous Cell Carcinoma of Head and Neck ; Studies ; Systematic review ; Throat cancer ; Tobacco
É parte de: PloS one, 2013-03, Vol.8 (3), p.e58158
Notas: Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: AAK JJ GG. Performed the experiments: AAK GG. Analyzed the data: AAK JJ UG. Contributed reagents/materials/analysis tools: AAK JJ GG UG. Wrote the paper: AAK JJ GG UG.
Descrição: To evaluate the effect of alcohol cessation on the risk of developing laryngeal and pharyngeal cancers, combining available evidence in the scientific literature in a meta-analysis. A systematic literature review was conducted, and a meta-analysis was applied on the retrieved studies. The generalised least squares method was used to estimate the trend from dose-response data to assess changes in the risks of laryngeal and pharyngeal cancers after drinking cessation. A total of 9 case-control studies were included in the meta-analysis (4 and 8 estimates for laryngeal and pharyngeal cancers, respectively). On average, alcohol drinking cessation was associated with a 2% yearly reduction in the risk of developing laryngeal and pharyngeal cancers. There was a considerable heterogeneity between the studies of pharyngeal cancer, but this was mostly due to two studies. The increased risk of laryngeal and pharyngeal cancers caused by alcohol was reversible; the time periods until the risks became equal to those of never drinkers were 36 (95% CI 11-106) and 39 (95% CI 13-103) years, respectively. Moreover, 5 years of drinking cessation was associated with a reduction of around 15% in the alcohol-related elevated risk of laryngeal and pharyngeal cancers. Although a long time period is required to completely eliminate the alcohol-related elevated risk of laryngeal and pharyngeal cancers, a substantial risk reduction can be seen in the short term (5-10 years), and drinking cessation should therefore be encouraged to reduce the incidence of these cancers.
Editor: United States: Public Library of Science
Idioma: Inglês

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Alcohol drinking cessation and the risk of laryngeal and pharyngeal cancers: a systematic review and meta-analysis

Ahmad Kiadaliri, Aliasghar ; Jarl, Johan ; Gavriilidis, Georgios ; Gerdtham, Ulf-G Timmer, Antje

United States: Public Library of Science

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