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Impairment of cognitive function and synaptic plasticity associated with alteration of information flow in theta and gamma oscillations in melamine-treated rats

Xu, Xiaxia ; An, Lei ; Mi, Xichao ; Zhang, Tao Boraud, Thomas

PloS one, 2013-10, Vol.8 (10), p.e77796 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Impairment of cognitive function and synaptic plasticity associated with alteration of information flow in theta and gamma oscillations in melamine-treated rats
Autor: Xu, Xiaxia ; An, Lei ; Mi, Xichao ; Zhang, Tao
Boraud, Thomas
Assuntos: Algorithms ; Alterations ; Animals ; Cognition ; Cognition Disorders - chemically induced ; Cognitive ability ; Coherence length ; Education ; Electrophysiological Phenomena ; Frequency dependence ; Hippocampal plasticity ; Hippocampus ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Impairment ; Information flow ; Information management ; Laboratory animals ; Life sciences ; Long-term potentiation ; Long-Term Potentiation - drug effects ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Melamine ; Memory ; Neural plasticity ; Neuronal Plasticity - drug effects ; Neuronal Plasticity - physiology ; Neurons ; Oscillations ; Physiological aspects ; Plasticity ; Plasticity (neural) ; Potentiation ; Psychotropic drugs ; Rats ; Rats, Wistar ; Rodents ; Signal processing ; Studies ; Synaptic plasticity ; Synaptic transmission ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Synchronism ; Synchronization ; Theta Rhythm - drug effects ; Theta Rhythm - physiology ; Theta rhythms ; Triazines - toxicity
É parte de: PloS one, 2013-10, Vol.8 (10), p.e77796
Notas: Conceived and designed the experiments: TZ XX LA. Performed the experiments: XX LA. Analyzed the data: XX XM. Contributed reagents/materials/analysis tools: TZ XX. Wrote the paper: XX TZ.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Changes of neural oscillations at a variety of physiological rhythms are effectively associated with cognitive performance. The present study investigated whether the directional indices of neural information flow (NIF) could be used to symbolize the synaptic plasticity impairment in hippocampal CA3-CA1 network in a rat model of melamine. Male Wistar rats were employed while melamine was administered at a dose of 300 mg/kg/day for 4 weeks. Behavior was measured by the Morris water maze(MWM)test. Local field potentials (LFPs) were recorded before long-term potentiation (LTP) induction. Generalized partial directed coherence (gPDC) and phase-amplitude coupling conditional mutual information (PAC_CMI) were used to measure the unidirectional indices in both theta and low gamma oscillations (LG, ~ 30-50 Hz). Our results showed that melamine induced the cognition deficits consistent with the reduced LTP in CA1 area. Phase locking values (PLVs) showed that the synchronization between CA3 and CA1 in both theta and LG rhythms was reduced by melamine. In both theta and LG rhythms, unidirectional indices were significantly decreased in melamine treated rats while a similar variation trend was observed in LTP reduction, implying that the effects of melamine on cognitive impairment were possibly mediated via profound alterations of NIF on CA3-CA1 pathway in hippocampus. The results suggested that LFPs activities at these rhythms were most likely involved in determining the alterations of information flow in the hippocampal CA3-CA1 network, which might be associated with the alteration of synaptic transmission to some extent.
Editor: United States: Public Library of Science
Idioma: Inglês

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Impairment of cognitive function and synaptic plasticity associated with alteration of information flow in theta and gamma oscillations in melamine-treated rats

Xu, Xiaxia ; An, Lei ; Mi, Xichao ; Zhang, Tao Boraud, Thomas

United States: Public Library of Science

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