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Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults

Albareda, María C ; De Rissio, Ana M ; Tomas, Gonzalo ; Serjan, Alicia ; Alvarez, María G ; Viotti, Rodolfo ; Fichera, Laura E ; Esteva, Mónica I ; Potente, Daniel ; Armenti, Alejandro ; Tarleton, Rick L ; Laucella, Susana A Dumonteil, Eric

PLoS neglected tropical diseases, 2013-12, Vol.7 (12), p.e2575-e2575 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults
Autor: Albareda, María C ; De Rissio, Ana M ; Tomas, Gonzalo ; Serjan, Alicia ; Alvarez, María G ; Viotti, Rodolfo ; Fichera, Laura E ; Esteva, Mónica I ; Potente, Daniel ; Armenti, Alejandro ; Tarleton, Rick L ; Laucella, Susana A
Dumonteil, Eric
Assuntos: Adolescent ; Adult ; CD40 Ligand - analysis ; Chagas Disease - immunology ; Child ; Child, Preschool ; Comparative analysis ; Enzyme-Linked Immunospot Assay ; Female ; Flow Cytometry ; Health aspects ; Host-parasite relationships ; Humans ; Immune system ; Immunophenotyping ; Infections ; Interferon-gamma - metabolism ; Interleukin-2 - metabolism ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Parasites ; Physiological aspects ; Protozoa ; T cells ; T-Lymphocytes - chemistry ; T-Lymphocytes - immunology ; Tropical diseases ; Trypanosoma cruzi ; Trypanosoma cruzi - immunology ; Tumor Necrosis Factor-alpha - metabolism
É parte de: PLoS neglected tropical diseases, 2013-12, Vol.7 (12), p.e2575-e2575
Notas: ObjectType-Article-2
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Conceived and designed the experiments: SAL MCA RLT. Performed the experiments: MCA SAL MGA AMDR AA DP GT AS MIE LEF. Analyzed the data: MCA SAL MGA RV. Contributed reagents/materials/analysis tools: SAL RLT. Wrote the paper: SAL RLT MCA.
The authors have declared that no competing interests exist.
Descrição: Adults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells. It is possible that persistent infection and/or sustained exposure to parasites antigens may lead to a progressive loss of function of the immune T cells. To test this hypothesis, the quality and magnitude of T. cruzi-specific T cell responses were evaluated in T. cruzi-infected children and compared with long-term T. cruzi-infected adults with no evidence of heart failure. The phenotype of CD4(+) T cells was also assessed in T. cruzi-infected children and uninfected controls. Simultaneous secretion of IFN-γ and IL-2 measured by ELISPOT assays in response to T. cruzi antigens was prevalent among T. cruzi-infected children. Flow cytometric analysis of co-expression profiles of CD4(+) T cells with the ability to produce IFN-γ, TNF-α, or to express the co-stimulatory molecule CD154 in response to T. cruzi showed polyfunctional T cell responses in most T. cruzi-infected children. Monofunctional T cell responses and an absence of CD4(+)TNF-α(+)-secreting T cells were observed in T. cruzi-infected adults. A relatively high degree of activation and differentiation of CD4(+) T cells was evident in T. cruzi-infected children. Our observations are compatible with our initial hypothesis that persistent T. cruzi infection promotes eventual exhaustion of immune system, which might contribute to disease progression in long-term infected subjects.
Editor: United States: Public Library of Science
Idioma: Inglês

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Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults

Albareda, María C ; De Rissio, Ana M ; Tomas, Gonzalo ; Serjan, Alicia ; Alvarez, María G ; Viotti, Rodolfo ; Fichera, Laura E ; Esteva, Mónica I ; Potente, Daniel ; Armenti, Alejandro ; Tarleton, Rick L ; Laucella, Susana A Dumonteil, Eric

United States: Public Library of Science

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