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Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect

Valcz, Gábor ; Patai, Arpád V ; Kalmár, Alexandra ; Péterfia, Bálint ; Fűri, István ; Wichmann, Barnabás ; Műzes, Györgyi ; Sipos, Ferenc ; Krenács, Tibor ; Mihály, Emese ; Spisák, Sándor ; Molnár, Béla ; Tulassay, Zsolt Cukierman, Edna

PloS one, 2014-11, Vol.9 (11), p.e106143-e106143 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect
Autor: Valcz, Gábor ; Patai, Arpád V ; Kalmár, Alexandra ; Péterfia, Bálint ; Fűri, István ; Wichmann, Barnabás ; Műzes, Györgyi ; Sipos, Ferenc ; Krenács, Tibor ; Mihály, Emese ; Spisák, Sándor ; Molnár, Béla ; Tulassay, Zsolt
Cukierman, Edna
Assuntos: Apoptosis ; Biology and life sciences ; Biopsy ; Cancer ; Carcinoma ; Carcinoma - metabolism ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - metabolism ; DNA Methylation ; Epigenetic inheritance ; Epigenetics ; Epithelial cells ; Epithelium ; Ethics ; Frizzled protein ; Frizzled-related protein ; Frizzled-related protein 1 ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; HCT116 Cells ; Homeostasis ; Humans ; Inhibitors ; Intercellular Signaling Peptides and Proteins - genetics ; Intercellular Signaling Peptides and Proteins - metabolism ; Internal medicine ; Medical research ; Medicine ; Medicine and Health Sciences ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mutation ; Myofibroblasts - metabolism ; Paracrine signalling ; Prostate cancer ; Proteins ; Stroma ; Tissues ; Tumors ; Wnt protein
É parte de: PloS one, 2014-11, Vol.9 (11), p.e106143-e106143
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: GV AVP. Performed the experiments: GV AVP AK BP IF. Analyzed the data: GV AVP AK BP IF BW GM FS TK EM SS BM ZT. Contributed reagents/materials/analysis tools: TK EM SS BM ZT. Wrote the paper: GV AVP AK BP IF BW GM FS TK EM SS BM ZT. Statistical analysis: BW.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Epigenetic changes of stromal-epithelial interactions are of key importance in the regulation of colorectal carcinoma (CRC) cells and morphologically normal, but genetically and epigenetically altered epithelium in normal adjacent tumor (NAT) areas. Here we demonstrated retained protein expression of well-known Wnt inhibitor, secreted frizzled-related protein 1 (SFRP1) in stromal myofibroblasts and decreasing epithelial expression from NAT tissues towards the tumor. SFRP1 was unmethylated in laser microdissected myofibroblasts and partially hypermethylated in epithelial cells in these areas. In contrast, we found epigenetically silenced myofibroblast-derived SFRP1 in CRC stroma. Our results suggest that the myofibroblast-derived SFRP1 protein might be a paracrine inhibitor of epithelial proliferation in NAT areas and loss of this signal may support tumor proliferation in CRC.
Editor: United States: Public Library of Science
Idioma: Inglês

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Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect

Valcz, Gábor ; Patai, Arpád V ; Kalmár, Alexandra ; Péterfia, Bálint ; Fűri, István ; Wichmann, Barnabás ; Műzes, Györgyi ; Sipos, Ferenc ; Krenács, Tibor ; Mihály, Emese ; Spisák, Sándor ; Molnár, Béla ; Tulassay, Zsolt Cukierman, Edna

United States: Public Library of Science

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