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IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice

Ali, Abukar ; Na, Manli ; Svensson, Mattias N D ; Magnusson, Malin ; Welin, Amanda ; Schwarze, Jan-Christoph ; Mohammad, Majd ; Josefsson, Elisabet ; Pullerits, Rille ; Jin, Tao Gao, Hongwei

PloS one, 2015-07, Vol.10 (7), p.e0131645-e0131645 [Peer Reviewed Journal]

United States: Public Library of Science

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Title:
IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice
Author: Ali, Abukar ; Na, Manli ; Svensson, Mattias N D ; Magnusson, Malin ; Welin, Amanda ; Schwarze, Jan-Christoph ; Mohammad, Majd ; Josefsson, Elisabet ; Pullerits, Rille ; Jin, Tao
Gao, Hongwei
Subjects: Animals ; Antibiotics ; Arthritis ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - microbiology ; Arthritis, Infectious ; Arthritis, Infectious - drug therapy ; Arthritis, Infectious - microbiology ; B cells ; Comparative analysis ; Cytokines ; Cytokines - metabolism ; Disease ; Disease Models, Animal ; Drug dosages ; Drug therapy ; Experiments ; Female ; Health aspects ; Health risks ; Immune system ; Immunologi inom det medicinska området ; Immunology in the medical area ; Infection ; Infectious arthritis ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Injury prevention ; Inoculation ; Interleukin 1 ; Interleukin 1 receptor antagonist ; Interleukin 1 Receptor Antagonist Protein - therapeutic use ; Intravenous administration ; Joint diseases ; Joints - pathology ; Kidney - pathology ; Laboratories ; Macrophages, Peritoneal - metabolism ; Medical research ; Medicine ; Mice ; Mortality ; Neutrophils ; Pneumonia ; Polyarthritis ; Rheumatology ; Rodents ; Sepsis ; Sepsis - drug therapy ; Sepsis - microbiology ; Staphylococcal infections ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus ; Staphylococcus aureus ; Staphylococcus infections ; Therapy ; TNF inhibitors ; X-Ray Microtomography
Is Part Of: PloS one, 2015-07, Vol.10 (7), p.e0131645-e0131645
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current Address: Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: AA EJ RP TJ. Performed the experiments: AA MN MNDS MMa AW JCS MMo EJ RP TJ. Analyzed the data: AA MN MNDS MMa AW JCS MMo EJ RP TJ. Wrote the paper: AA MN MNDS MMa AW JCS MMo EJ RP TJ.
Description: Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections. To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice. NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups. IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls. IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice.
Publisher: United States: Public Library of Science
Language: English

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IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice

Ali, Abukar ; Na, Manli ; Svensson, Mattias N D ; Magnusson, Malin ; Welin, Amanda ; Schwarze, Jan-Christoph ; Mohammad, Majd ; Josefsson, Elisabet ; Pullerits, Rille ; Jin, Tao Gao, Hongwei

United States: Public Library of Science

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