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Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, Ron ; Fuchs, Shai ; Milo, Ron

PLoS biology, 2016-08, Vol.14 (8), p.e1002533-e1002533 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Revised Estimates for the Number of Human and Bacteria Cells in the Body
Autor: Sender, Ron ; Fuchs, Shai ; Milo, Ron
Assuntos: Adult ; Bacteria ; Bacteria - cytology ; Bacteria - growth & development ; Bacterial Load ; Biology and Life Sciences ; Body Weights and Measures ; Cell Count ; Charitable foundations ; Colon ; Estimates ; Funding ; Human body ; Humans ; Male ; Medicine and Health Sciences ; Microbiota ; Organ Specificity ; People and Places ; Research and Analysis Methods
É parte de: PLoS biology, 2016-08, Vol.14 (8), p.e1002533-e1002533
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current address: Division of Endocrinology, The Hospital for Sick Children and Department of Pediatrics, The University of Toronto, Toronto, Canada
The authors have declared that no competing interests exist.
Descrição: Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human and bacterial cells in the body. We estimate the total number of bacteria in the 70 kg "reference man" to be 3.8·1013. For human cells, we identify the dominant role of the hematopoietic lineage to the total count (≈90%) and revise past estimates to 3.0·1013 human cells. Our analysis also updates the widely-cited 10:1 ratio, showing that the number of bacteria in the body is actually of the same order as the number of human cells, and their total mass is about 0.2 kg.
Editor: United States: Public Library of Science
Idioma: Inglês

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, Ron ; Fuchs, Shai ; Milo, Ron

United States: Public Library of Science

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