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The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats

Saeed Al-Wajeeh, Nahla ; Halabi, Mohammed Farouq ; Hajrezaie, Maryam ; M Dhiyaaldeen, Summaya ; Abdulaziz Bardi, Daleya ; M Salama, Suzy ; Rouhollahi, Elham ; Karimian, Hamed ; Abdolmalaki, Rojin ; Azizan, Ainnul Hamidah Syahadah ; Mohd Ali, Hapipah ; Mohd Noor, Suzita ; Abdulla, Mahmood Ameen Rajasingh, Johnson

PloS one, 2016-09, Vol.11 (9), p.e0157431-e0157431 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats
Autor: Saeed Al-Wajeeh, Nahla ; Halabi, Mohammed Farouq ; Hajrezaie, Maryam ; M Dhiyaaldeen, Summaya ; Abdulaziz Bardi, Daleya ; M Salama, Suzy ; Rouhollahi, Elham ; Karimian, Hamed ; Abdolmalaki, Rojin ; Azizan, Ainnul Hamidah Syahadah ; Mohd Ali, Hapipah ; Mohd Noor, Suzita ; Abdulla, Mahmood Ameen
Rajasingh, Johnson
Assuntos: Alcohol ; Alcohol, Denatured ; Animals ; Antioxidants ; Antioxidants (Nutrients) ; Bax protein ; Biological products ; Biology and Life Sciences ; Chromatography ; Cytotoxicity ; Drug dosages ; Edema ; Ethanol ; Gastric mucosa ; Health aspects ; Heat shock proteins ; Hemorrhage ; Herbal medicine ; Hsp70 protein ; Infiltration ; Leaves ; Lipid peroxidation ; Medical research ; Medicine ; Medicine and Health Sciences ; Medicine, Botanic ; Medicine, Herbal ; Omeprazole ; Oxidative stress ; Peroxidation ; Pharmaceutical industry ; Physical Sciences ; Plant extracts ; Proteins ; Rats ; Rodents ; Science ; Ulcers ; Vitex
É parte de: PloS one, 2016-09, Vol.11 (9), p.e0157431-e0157431
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: NSA MAA SMN HMA MH.Performed the experiments: NSA MH SMS SMD DAB MFH.Analyzed the data: NSA ER RA AHSA HK MFH.Contributed reagents/materials/analysis tools: NSA MAA SMN MH.Wrote the paper: NSA.Revised and approved the manuscript: MAA MH.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Vitex pubescens is a Malaysian therapeutic plant employed in traditional drug to remedy a variety of disorders. The purpose of this research is to assess the gastroprotective efficiency of V. pubescens leaves against ethanol-induced gastric hemorrhagic laceration in rats. Animals were randomly allocated into seven groups and pre-treated, separately, with 10% Tween 20 (normal and ulcer control groups), 20 mg/kg omeprazole (reference group), and 62.5, 125, 250, and 500 mg/kg of V. pubescens extract (experimental groups). All animals were sacrificed after another hour. Histological evaluation of the ulcer control group revealed significant injury to the gastric mucosa with edema and leucocyte infiltration of the submucosal layer. PAS staining, showed remarkably intense magenta color, remarkable increase of HSP70 and decrease of Bax proteins in rats pre-treated with plant extracts compared to the ulcer control group. Gastric homogenates revealed a remarkable increase in endogenous antioxidant enzyme activities (CAT, SOD, GSH) and a decrease in the lipid peroxidation level (MDA) in animals pre-treated with V. pubescens extract compared with the ulcer control group. The gastroprotective activity of this plant might be related to increased antioxidant enzymes and decrease lipid peroxidation upsurge of HSP70 and reduced expression of Bax proteins.
Editor: United States: Public Library of Science
Idioma: Inglês

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The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats

United States: Public Library of Science

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