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Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature

Kong, Hoi-Kuan ; Law, Hon-Wai ; Liu, Xuan ; Law, Carmen O K ; Pan, Qing ; Gao, Lin ; Xiong, Lifeng ; Lau, Susanna K P ; Woo, Patrick C Y ; Lau, Terrence Chi Kong Yang, Shihui

PloS one, 2017-01, Vol.12 (1), p.e0169998-e0169998 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature
Autor: Kong, Hoi-Kuan ; Law, Hon-Wai ; Liu, Xuan ; Law, Carmen O K ; Pan, Qing ; Gao, Lin ; Xiong, Lifeng ; Lau, Susanna K P ; Woo, Patrick C Y ; Lau, Terrence Chi Kong
Yang, Shihui
Assuntos: Adaptation ; Adaptation, Physiological - genetics ; Anaerobic conditions ; Analysis ; Antimicrobial agents ; Bacillus ; Bacteria ; Biology and Life Sciences ; Biomarkers - metabolism ; Body temperature ; Body temperatures ; Chemotherapy ; Cirrhosis ; Drinking water ; Environmental conditions ; Fish ; Freshwater fish ; Gastroenteritis ; Gastroenteritis - genetics ; Gastroenteritis - microbiology ; Gene expression ; Genetic aspects ; Genome, Bacterial ; Genomes ; High-Throughput Nucleotide Sequencing - methods ; Humans ; Immune response ; Immunity ; Infections ; Intestine ; Laribacter hongkongensis ; Liver ; Liver cirrhosis ; Medicine and Health Sciences ; Microbiology ; Neisseriaceae - genetics ; Neisseriaceae - isolation & purification ; Pathogenesis ; Pathways ; Physiological aspects ; Physiology ; Proteins ; Proteobacteria ; Pseudomonas aeruginosa ; Research and analysis methods ; RNA, Bacterial - genetics ; Stress, Physiological ; Survival ; Temperature ; Temperature effects ; Temperature requirements ; Territorial transfers ; Urease ; Zebrafish
É parte de: PloS one, 2017-01, Vol.12 (1), p.e0169998-e0169998
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Conceptualization: SKPL PCYW TCKL.Data curation: QP LX.Formal analysis: HK HL XL COKL.Funding acquisition: SKPL PCYW TCKL.Investigation: HK HL XL QP.Methodology: HK HL COKL QP.Project administration: TCKL.Resources: SKPL PCYW TCKL.Supervision: SKPL PCYW TCKL.Validation: HK HL COKL LX.Visualization: HK HL LG.Writing – original draft: HK XL TCKL.Writing – review & editing: HK TCKL.
Descrição: Bacterial adaptation to different hosts requires transcriptomic alteration in response to the environmental conditions. Laribacter hongkongensis is a gram-negative, facultative anaerobic, urease-positive bacillus caused infections in liver cirrhosis patients and community-acquired gastroenteritis. It was also found in intestine from commonly consumed freshwater fishes and drinking water reservoirs. Since L. hongkongensis could survive as either fish or human pathogens, their survival mechanisms in two different habitats should be temperature-regulated and highly complex. Therefore, we performed transcriptomic analysis of L. hongkongensis at body temperatures of fish and human in order to elucidate the versatile adaptation mechanisms coupled with the temperatures. We identified numerous novel temperature-induced pathways involved in host pathogenesis, in addition to the shift of metabolic equilibriums and overexpression of stress-related proteins. Moreover, these pathways form a network that can be activated at a particular temperature, and change the physiology of the bacteria to adapt to the environments. In summary, the dynamic of transcriptomes in L. hongkongensis provides versatile strategies for the bacterial survival at different habitats and this alteration prepares the bacterium for the challenge of host immunity.
Editor: United States: Public Library of Science
Idioma: Inglês

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Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature

Kong, Hoi-Kuan ; Law, Hon-Wai ; Liu, Xuan ; Law, Carmen O K ; Pan, Qing ; Gao, Lin ; Xiong, Lifeng ; Lau, Susanna K P ; Woo, Patrick C Y ; Lau, Terrence Chi Kong Yang, Shihui

United States: Public Library of Science

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