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Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects

Guimarães, Luiz Henrique ; Queiroz, Adriano ; Silva, Juliana A ; Silva, Silvana C ; Magalhães, Viviane ; Lago, Ednaldo L ; Machado, Paulo Roberto L ; Bacellar, Olívia ; Wilson, Mary E ; Beverley, Stephen M ; Carvalho, Edgar M ; Schriefer, Albert McDowell, Mary Ann

PLoS neglected tropical diseases, 2016-12, Vol.10 (12), p.e0005100-e0005100 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
Autor: Guimarães, Luiz Henrique ; Queiroz, Adriano ; Silva, Juliana A ; Silva, Silvana C ; Magalhães, Viviane ; Lago, Ednaldo L ; Machado, Paulo Roberto L ; Bacellar, Olívia ; Wilson, Mary E ; Beverley, Stephen M ; Carvalho, Edgar M ; Schriefer, Albert
McDowell, Mary Ann
Assuntos: Adolescent ; Adult ; Analysis ; Antigens ; Biology and Life Sciences ; Brazil - epidemiology ; Care and treatment ; Colleges & universities ; Cutaneous leishmaniasis ; Cytokines ; Diagnosis ; Endemic Diseases ; Female ; Funding ; Hospitals ; Humans ; Immunology ; Interferon-gamma - genetics ; Interferon-gamma - immunology ; Interleukin-17 - genetics ; Interleukin-17 - immunology ; Leishmania braziliensis - genetics ; Leishmania braziliensis - isolation & purification ; Leishmania braziliensis - physiology ; Leishmaniasis, Cutaneous ; Leishmaniasis, Cutaneous - epidemiology ; Leishmaniasis, Cutaneous - immunology ; Leishmaniasis, Cutaneous - parasitology ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - parasitology ; Male ; Medicine and Health Sciences ; Middle Aged ; Parasites ; Parasitic diseases ; Pathogenesis ; People and places ; Physical Sciences ; Physiological aspects ; Polymorphism, Single Nucleotide ; Tropical diseases ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - immunology ; Young Adult
É parte de: PLoS neglected tropical diseases, 2016-12, Vol.10 (12), p.e0005100-e0005100
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceptualization: AS LHG EMC. Formal analysis: LHG AQ JAS OB MEW SMB AS. Funding acquisition: EMC PRLM MEW AS. Investigation: LHG AQ JAS SCS VM ELL AS. Methodology: AQ JAS SCS VM ELL PRLM OB. Project administration: AS. Supervision: AS. Writing – original draft: LHG AQ EMC AS. Writing – review & editing: SMB MEW.
The authors have declared that no competing interests exist.
Descrição: Atypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL. Between 2005 and 2012, 51 ACL (cases) and 51 temporally matched cutaneous leishmaniasis (CL) subjects (controls) were enrolled and followed over time in Corte de Pedra. Clinical and therapeutic data were recorded for all subjects. Cytokine secretion by patients' peripheral blood mononuclear cells (PBMC) stimulated with soluble parasite antigen in vitro, and genotypes in a 600 base-pair locus in chromosome 28 (CHR28/425451) of the infecting L. (V.) braziliensis were compared between the two groups. ACL presented significantly more lesions in head and neck, and higher rate of antimony failure than CL. Cytosine-Adenine substitutions at CHR28/425451 positions 254 and 321 were highly associated with ACL (p<0.0001). In vitro stimulated ACL PBMCs produced lower levels of IFN-γ (p = 0.0002) and TNF (p <0.0001), and higher levels of IL-10 (p = 0.0006) and IL-17 (p = 0.0008) than CL PBMCs. ACL found in Northeast Brazil is caused by distinct genotypes of L. (V.) braziliensis and presents a cytokine profile that departs from that in classical CL patients. We think that differences in antigenic contents among parasites may be in part responsible for the variation in cytokine responses and possibly immunopathology between CL and ACL.
Editor: United States: Public Library of Science
Idioma: Inglês

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Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects

Guimarães, Luiz Henrique ; Queiroz, Adriano ; Silva, Juliana A ; Silva, Silvana C ; Magalhães, Viviane ; Lago, Ednaldo L ; Machado, Paulo Roberto L ; Bacellar, Olívia ; Wilson, Mary E ; Beverley, Stephen M ; Carvalho, Edgar M ; Schriefer, Albert McDowell, Mary Ann

United States: Public Library of Science

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