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Assessment of treatment response during chemoradiation therapy for pancreatic cancer based on quantitative radiomic analysis of daily CTs: An exploratory study

Chen, Xiaojian ; Oshima, Kiyoko ; Schott, Diane ; Wu, Hui ; Hall, William ; Song, Yingqiu ; Tao, Yalan ; Li, Dingjie ; Zheng, Cheng ; Knechtges, Paul ; Erickson, Beth ; Li, X Allen Batra, Surinder K.

PloS one, 2017-06, Vol.12 (6), p.e0178961-e0178961 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Assessment of treatment response during chemoradiation therapy for pancreatic cancer based on quantitative radiomic analysis of daily CTs: An exploratory study
Autor: Chen, Xiaojian ; Oshima, Kiyoko ; Schott, Diane ; Wu, Hui ; Hall, William ; Song, Yingqiu ; Tao, Yalan ; Li, Dingjie ; Zheng, Cheng ; Knechtges, Paul ; Erickson, Beth ; Li, X Allen
Batra, Surinder K.
Assuntos: Aged ; Amplification ; Aorta ; Biology ; Biology and Life Sciences ; Brain cancer ; Cancer ; Cancer therapies ; Care and treatment ; Chemoradiotherapy ; Chemoradiotherapy - methods ; Chemotherapy ; Computed tomography ; Contours ; Data acquisition ; Diagnostic systems ; Energy ; Entropy ; Female ; Head & neck cancer ; Health aspects ; Histograms ; Hospitals ; Humans ; Kurtosis ; Liver ; Male ; Mathematical models ; Medical imaging ; Medicine and Health Sciences ; Middle Aged ; Oncology ; Pancreas ; Pancreas - diagnostic imaging ; Pancreas - drug effects ; Pancreas - radiation effects ; Pancreatic cancer ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - drug therapy ; Pancreatic Neoplasms - radiotherapy ; Pancreatic Neoplasms - therapy ; Pathology ; Patients ; Physical Sciences ; Physics ; Quantitative analysis ; Radiation ; Radiation effects ; Radiation therapy ; Radiomics ; Radiotherapy ; Rails ; Reimbursement ; Rope ; Skewness ; Spinal cord ; Standard deviation ; Therapy ; Tomography, X-Ray Computed - methods ; Treatment Outcome ; Tumors
É parte de: PloS one, 2017-06, Vol.12 (6), p.e0178961-e0178961
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceptualization: XAL.Data curation: XC KO DS WH YS HW YT DL CZ PK BE XAL.Formal analysis: XC KO DS WH YS HW YT DL CZ PK BE XAL.Investigation: XC KO DS WH YS HW YT DL CZ PK BE XAL.Methodology: XC KO WH CZ XAL.Project administration: XAL.Resources: KO WH PK BE XAL.Software: XC DS XAL.Supervision: XAL.Validation: XC KO DS WH YS HW YT DL CZ PK BE XAL.Visualization: XC KO DS WH YS HW YT DL CZ PK BE XAL.Writing – original draft: XC KO DS WH YS HW DL CZ PK BE XAL.Writing – review & editing: XC KO DS WH YS HW YT DL CZ PK BE XAL.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: In an effort for early assessment of treatment response, we investigate radiation induced changes in quantitative CT features of tumor during the delivery of chemoradiation therapy (CRT) for pancreatic cancer. Diagnostic-quality CT data acquired daily during routine CT-guided CRT using a CT-on-rails for 20 pancreatic head cancer patients were analyzed. On each daily CT, the pancreatic head, the spinal cord and the aorta were delineated and the histograms of CT number (CTN) in these contours were extracted. Eight histogram-based radiomic metrics including the mean CTN (MCTN), peak position, volume, standard deviation (SD), skewness, kurtosis, energy and entropy were calculated for each fraction. Paired t-test was used to check the significance of the change of specific metric at specific time. GEE model was used to test the association between changes of metrics over time for different pathology responses. In general, CTN histogram in the pancreatic head (but not in spinal cord) changed during the CRT delivery. Changes from the 1st to the 26th fraction in MCTN ranged from -15.8 to 3.9 HU with an average of -4.7 HU (p<0.001). Meanwhile the volume decreased, the skewness increased (less skewed), and the kurtosis decreased (less peaked). The changes of MCTN, volume, skewness, and kurtosis became significant after two weeks of treatment. Patient pathological response is associated with the changes of MCTN, SD, and skewness. In cases of good response, patients tend to have large reductions in MCTN and skewness, and large increases in SD and kurtosis. Significant changes in CT radiomic features, such as the MCTN, skewness, and kurtosis in tumor were observed during the course of CRT for pancreas cancer based on quantitative analysis of daily CTs. These changes may be potentially used for early assessment of treatment response and stratification for therapeutic intensification.
Editor: United States: Public Library of Science
Idioma: Inglês

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Assessment of treatment response during chemoradiation therapy for pancreatic cancer based on quantitative radiomic analysis of daily CTs: An exploratory study

Chen, Xiaojian ; Oshima, Kiyoko ; Schott, Diane ; Wu, Hui ; Hall, William ; Song, Yingqiu ; Tao, Yalan ; Li, Dingjie ; Zheng, Cheng ; Knechtges, Paul ; Erickson, Beth ; Li, X Allen Batra, Surinder K.

United States: Public Library of Science

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