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A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

Bell, Kirsten E ; Snijders, Tim ; Zulyniak, Michael ; Kumbhare, Dinesh ; Parise, Gianni ; Chabowski, Adrian ; Phillips, Stuart M Fisher, Gordon

PloS one, 2017-07, Vol.12 (7), p.e0181387-e0181387 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial
Autor: Bell, Kirsten E ; Snijders, Tim ; Zulyniak, Michael ; Kumbhare, Dinesh ; Parise, Gianni ; Chabowski, Adrian ; Phillips, Stuart M
Fisher, Gordon
Assuntos: Acids ; Aged ; Aging ; Biology and Life Sciences ; Blood pressure ; Body Composition - drug effects ; Body mass ; Body mass index ; Calcium ; Clinical trials ; Consumption ; Creatine ; Diabetes ; Dietary Supplements ; Exercise ; Exercise - physiology ; Fasting - blood ; Female ; Fitness training programs ; Food and nutrition ; Frailty ; Health aspects ; Healthy Volunteers ; Humans ; Kinesiology ; Lean body mass ; Lipids - blood ; Male ; Maltodextrin ; Medicine and Health Sciences ; Men ; Mens health ; Metabolism ; Middle aged men ; Muscle strength ; Muscle Strength - drug effects ; Muscles ; Muscular strength ; Musculoskeletal system ; Older people ; People and Places ; Physical fitness ; Physical sciences ; Physical training ; Physiological aspects ; Proteins ; Repetition ; Rodents ; Sarcopenia ; Skeletal muscle ; Strength training ; Vitamin D ; Whey ; Whey protein ; Whey Proteins - pharmacology
É parte de: PloS one, 2017-07, Vol.12 (7), p.e0181387-e0181387
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Competing Interests: The authors have read the journal's policy and the authors of this manuscript have the following competing interests: SMP reports receipt of competitive grant support, travel expenses, and honoraria for speaking received from the US National Dairy Council. No other conflicts of interest, financial or otherwise, are reported by any of the authors. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Descrição: Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Σ1RM, SUPP: +14 ± 4 kg, CON: +3 ± 2 kg, P < 0.001) and lean mass (LBM, +1.2 ± 0.3 kg, CON: -0.1 ± 0.2 kg, P < 0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Σ upper body 1RM: 119 ± 4 vs. 109 ± 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training. ClinicalTrials.gov NCT02281331.
Editor: United States: Public Library of Science
Idioma: Inglês

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A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

Bell, Kirsten E ; Snijders, Tim ; Zulyniak, Michael ; Kumbhare, Dinesh ; Parise, Gianni ; Chabowski, Adrian ; Phillips, Stuart M Fisher, Gordon

United States: Public Library of Science

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