Idioma:

Small heat shock proteins determine synapse number and neuronal activity during development

Santana, Elena ; de Los Reyes, Teresa ; Casas-Tintó, Sergio Kampinga, Harm H.

PloS one, 2020-05, Vol.15 (5), p.e0233231-e0233231 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Small heat shock proteins determine synapse number and neuronal activity during development
Autor: Santana, Elena ; de Los Reyes, Teresa ; Casas-Tintó, Sergio
Kampinga, Harm H.
Assuntos: Accumulation ; Analysis ; Antibodies ; Biochemistry ; Biology and Life Sciences ; Cell cycle ; Cell death ; Chaperones ; Coupling (molecular) ; DNA binding proteins ; Drosophila ; Environmental changes ; Fruit flies ; Gene expression ; Heat shock proteins ; Immunomodulation ; Insects ; Kinases ; Medicine and Health Sciences ; Modulators ; Nervous system ; Neural circuitry ; Neural transmission ; Neurogenesis ; Neuromodulation ; Neurons ; Novels ; Oxygen ; Physiological aspects ; Prejudice ; Protein folding ; Proteins ; Reactive oxygen species ; Research and Analysis Methods ; Small heat shock proteins ; Synaptic transmission ; Synaptogenesis ; Transcription factors
É parte de: PloS one, 2020-05, Vol.15 (5), p.e0233231-e0233231
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Environmental changes cause stress, Reactive Oxygen Species and unfolded protein accumulation which hamper synaptic activity and trigger cell death. Heat shock proteins (HSPs) assist protein refolding to maintain proteostasis and cellular integrity. Mechanisms regulating the activity of HSPs include transcription factors and posttranslational modifications that ensure a rapid response. HSPs preserve synaptic function in the nervous system upon environmental insults or pathological factors and contribute to the coupling between environmental cues and neuron control of development. We have performed a biased screening in Drosophila melanogaster searching for synaptogenic modulators among HSPs during development. We explore the role of two small-HSPs (sHSPs), sHSP23 and sHSP26 in synaptogenesis and neuronal activity. Both sHSPs immunoprecipitate together and the equilibrium between both chaperones is required for neuronal development and activity. The molecular mechanism controlling HSP23 and HSP26 accumulation in neurons relies on a novel gene (CG1561), which we name Pinkman (pkm). We propose that sHSPs and Pkm are targets to modulate the impact of stress in neurons and to prevent synapse loss.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Small heat shock proteins determine synapse number and neuronal activity during development

Santana, Elena ; de Los Reyes, Teresa ; Casas-Tintó, Sergio Kampinga, Harm H.

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.