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State transitions through inhibitory interneurons in a cortical network model

Bryson, Alexander ; Berkovic, Samuel F ; Petrou, Steven ; Grayden, David B Graham, Lyle J.

PLoS computational biology, 2021-10, Vol.17 (10), p.e1009521-e1009521 [Revista revisada por pares]

United States: Public Library of Science

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Título:
State transitions through inhibitory interneurons in a cortical network model
Autor: Bryson, Alexander ; Berkovic, Samuel F ; Petrou, Steven ; Grayden, David B
Graham, Lyle J.
Materias: Action Potentials - physiology ; Animals ; Computational Biology ; Computational neuroscience ; Excitability ; Gene expression ; Interneurons ; Interneurons - cytology ; Interneurons - physiology ; Latency ; Mice ; Models, Neurological ; Modulation ; Nerve Net - cytology ; Nerve Net - physiology ; Network latency ; Neural networks ; Neurons ; Oscillations ; Physiological aspects ; Population ; Sample variance ; Somatosensory Cortex - cytology ; Somatosensory Cortex - physiology ; Spiking
Es parte de: PLoS computational biology, 2021-10, Vol.17 (10), p.e1009521-e1009521
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The authors have declared that no competing interests exist.
Descripción: Inhibitory interneurons shape the spiking characteristics and computational properties of cortical networks. Interneuron subtypes can precisely regulate cortical function but the roles of interneuron subtypes for promoting different regimes of cortical activity remains unclear. Therefore, we investigated the impact of fast spiking and non-fast spiking interneuron subtypes on cortical activity using a network model with connectivity and synaptic properties constrained by experimental data. We found that network properties were more sensitive to modulation of the fast spiking population, with reductions of fast spiking excitability generating strong spike correlations and network oscillations. Paradoxically, reduced fast spiking excitability produced a reduction of global excitation-inhibition balance and features of an inhibition stabilised network, in which firing rates were driven by the activity of excitatory neurons within the network. Further analysis revealed that the synaptic interactions and biophysical features associated with fast spiking interneurons, in particular their rapid intrinsic response properties and short synaptic latency, enabled this state transition by enhancing gain within the excitatory population. Therefore, fast spiking interneurons may be uniquely positioned to control the strength of recurrent excitatory connectivity and the transition to an inhibition stabilised regime. Overall, our results suggest that interneuron subtypes can exert selective control over excitatory gain allowing for differential modulation of global network state.
Editor: United States: Public Library of Science
Idioma: Inglés

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State transitions through inhibitory interneurons in a cortical network model

Bryson, Alexander ; Berkovic, Samuel F ; Petrou, Steven ; Grayden, David B Graham, Lyle J.

United States: Public Library of Science

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