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Azithromycin consumption during the COVID-19 pandemic in Croatia, 2020

Bogdanić, Nikolina ; Močibob, Loris ; Vidović, Toni ; Soldo, Ana ; Begovać, Josip Karunasagar, Iddya

PloS one, 2022-02, Vol.17 (2), p.e0263437-e0263437 [Periódico revisado por pares]

United States: Public Library of Science

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Azithromycin consumption during the COVID-19 pandemic in Croatia, 2020
Autor: Bogdanić, Nikolina ; Močibob, Loris ; Vidović, Toni ; Soldo, Ana ; Begovać, Josip
Karunasagar, Iddya
Assuntos: Anti-Bacterial Agents ; Anti-Infective Agents ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Antiviral Agents - therapeutic use ; Azithromycin ; Azithromycin - therapeutic use ; Biology and Life Sciences ; Consumption ; Consumption data ; Coronaviruses ; COVID-19 ; COVID-19 - drug therapy ; Croatia ; Croatia - epidemiology ; Data collection ; Databases, Factual ; Dosage and administration ; Drug stores ; Drug Therapy, Combination ; Drug Utilization - trends ; Drugstores ; Epidemics ; Hospitalization ; Hospitals ; Humans ; Hydroxychloroquine ; Hydroxychloroquine - therapeutic use ; Infectious diseases ; Inhabitants ; Medicine and Health Sciences ; Pandemics ; People and places ; Pharmacy ; Population ; Practice Patterns, Physicians' - statistics & numerical data ; Practice Patterns, Physicians' - trends ; SARS-CoV-2 - drug effects ; SARS-CoV-2 - pathogenicity ; Social networks ; Software
É parte de: PloS one, 2022-02, Vol.17 (2), p.e0263437-e0263437
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Competing Interests: This commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.
Descrição: During the initial phase of the COVID-19 pandemic, there was great enthusiasm for the use of azithromycin with or without hydroxychloroquine. We analyzed azithromycin consumption in Croatia in 2020 and compared this to the period 2017-2019. Azithromycin consumption was evaluated using the IQVIA Adriatic d.o.o. database which collects data on azithromycin distribution from wholesale pharmacies to hospital and non-hospital pharmacies in Croatia. We analyzed data for the period from January 2017 to December 2020. Azithromycin distribution was measured as days of therapy (DOT) and reported as per 1000 inhabitants or per 1000 inhabitant-days. In the period 2017-2020, total azithromycin DOT in Croatia increased in 2017, 2018, 2019, and 2020 (1.76, 1.91, 1.91 and 2.01/1000 inhabitant-days, respectively). Non-hospital pharmacies received 2.18 times and hospital pharmacies 4.39 times more DOT units/1000 inhabitants of azithromycin in March 2020 compared to the average distribution rate in March 2017-2019. During the peak of the COVID-19 epidemic (November and December 2020) azithromycin distribution increased considerably in hospital (3.62 and 3.19 times, respectively) and non-hospital pharmacies (1.93 and 1.84 times, respectively) compared to the average consumption in the same months in 2017-2019. Our data showed increased azithromycin distribution in the period 2017-2020 which indicates azithromycin overuse. Preliminary information on COVID-19 treatments with a desire to offer and try what is available even in the absence of strong scientific evidence may have influenced practices of antimicrobial prescriptions.
Editor: United States: Public Library of Science
Idioma: Inglês

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Azithromycin consumption during the COVID-19 pandemic in Croatia, 2020

Bogdanić, Nikolina ; Močibob, Loris ; Vidović, Toni ; Soldo, Ana ; Begovać, Josip Karunasagar, Iddya

United States: Public Library of Science

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