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Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography

Kim, Cherry ; Kim, Ji-Yeon ; Lee, Eun Joo ; Kang, Yu Min ; Song, Kyoung-Ho ; Kim, Eu Suk ; Kim, Eun Jin ; Sheen, Seungsoo ; Lee, Yoo Ra ; Kang, BeoDeul ; Kim, Joon Ho ; Woo, Myoung Lyeol ; Park, Chul Hee ; Kwon, Soohoon ; Choo, Eun Ju ; Kim, Tark ; Kim, Donghoon ; Oh, Hong Sang ; Choi, Won Suk Sobh, Eman

PloS one, 2022-03, Vol.17 (3), p.e0264711-e0264711 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography
Autor: Kim, Cherry ; Kim, Ji-Yeon ; Lee, Eun Joo ; Kang, Yu Min ; Song, Kyoung-Ho ; Kim, Eu Suk ; Kim, Eun Jin ; Sheen, Seungsoo ; Lee, Yoo Ra ; Kang, BeoDeul ; Kim, Joon Ho ; Woo, Myoung Lyeol ; Park, Chul Hee ; Kwon, Soohoon ; Choo, Eun Ju ; Kim, Tark ; Kim, Donghoon ; Oh, Hong Sang ; Choi, Won Suk
Sobh, Eman
Assuntos: Adult ; Age ; Aged ; Armed forces ; Biology and Life Sciences ; Chest ; Computed tomography ; Confidence intervals ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 - virology ; CT imaging ; Cyclic loads ; Female ; Fever ; Heart failure ; Hospitals ; Humans ; Infectious diseases ; Internal medicine ; Male ; Measurement ; Medical diagnosis ; Medical imaging ; Medical research ; Medical schools ; Medicine ; Medicine and Health Sciences ; Medicine, Experimental ; Middle Aged ; Patients ; Pneumonia ; Population ; Predictive Value of Tests ; Prognosis ; Republic of Korea - epidemiology ; Research and Analysis Methods ; Retrospective Studies ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Sputum - virology ; Thorax - diagnostic imaging ; Tomography, X-Ray Computed ; Viral Load - physiology ; Viremia ; Young Adult
É parte de: PloS one, 2022-03, Vol.17 (3), p.e0264711-e0264711
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Reports detailing the clinical characteristics, viral load, and outcomes of patients with normal initial chest CT findings are lacking. We sought to compare the differences in clinical findings, viral loads, and outcomes between patients with confirmed COVID-19 who initially tested negative on chest CT (CT negative) with patients who tested initially positive on chest CT (CT positive). The clinical data, viral loads, and outcomes of initial CT-positive and CT-negative patients examined between January 2020 and April 2020 were retrospectively compared. The efficacy of viral load (cyclic threshold value [Ct value]) in predicting pneumonia was evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC). In total, 128 patients underwent initial chest CT (mean age, 54.3 ± 19.0 years, 50% male). Of those, 36 were initially CT negative, and 92 were CT positive. The CT-positive patients were significantly older (P < .001) than the CT-negative patients. Only age was significantly associated with the initial presence of pneumonia (odds ratio, 1.060; confidence interval (CI), 1.020-1-102; P = .003). In addition, age (OR, 1.062; CI, 1.014-1.112; P = .011), fever at diagnosis (OR, 6.689; CI, 1.715-26.096; P = .006), and CRP level (OR, 1.393; CI, 1.150-1.687; P = .001) were significantly associated with the need for O2 therapy. Viral load was significantly higher in the CT-positive group than in the CT-negative group (P = .017). The cutoff Ct value for predicting the presence of pneumonia was 27.71. Outcomes including the mean hospital stay, intensive care unit admission, and O2 therapy were significantly worse in the CT-positive group than in the CT-negative group (all P < .05). In conclusion, initially CT-negative patients showed better outcomes than initially CT-positive patients. Age was significantly associated with the initial presence of pneumonia, and viral load may help in predicting the initial presence of pneumonia.
Editor: United States: Public Library of Science
Idioma: Inglês

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Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography

United States: Public Library of Science

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