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Ingredients of a 2,000-y-old medicine revealed by chemical, mineralogical, and botanical investigations

Giachi, Gianna ; Pallecchi, Pasquino ; Romualdi, Antonella ; Ribechini, Erika ; Lucejko, Jeannette Jacqueline ; Colombini, Maria Perla ; Lippi, Marta Mariotti

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1193-1196 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Ingredients of a 2,000-y-old medicine revealed by chemical, mineralogical, and botanical investigations
Autor: Giachi, Gianna ; Pallecchi, Pasquino ; Romualdi, Antonella ; Ribechini, Erika ; Lucejko, Jeannette Jacqueline ; Colombini, Maria Perla ; Lippi, Marta Mariotti
Assuntos: Archaeology ; Bending ; Biological Sciences ; Chemical composition ; Chemistry ; Drug therapy ; Ethnobotany ; Fatty acids ; Grains ; Herbal medicine ; History, Ancient ; Humans ; Italy ; Lipids ; Medicine, Traditional - history ; Minerals ; Pharmacology ; Physical Sciences ; Plant Preparations - chemistry ; Plant Preparations - history ; Plants ; Plants, Medicinal - chemistry ; Pollen ; Ships - history ; Spectroscopy, Fourier Transform Infrared ; Starches ; Tablets - chemistry ; Tablets - history ; Writing tablets ; Zinc ; Zinc Compounds - analysis
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1193-1196
Notas: http://dx.doi.org/10.1073/pnas.1216776110
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Author contributions: G.G., E.R., and M.M.L. designed research; G.G., P.P., A.R., E.R., J.J.L., M.P.C., and M.M.L. performed research; G.G., P.P., E.R., J.J.L., and M.M.L. analyzed data; and G.G., P.P., E.R., and M.M.L. wrote the paper.
Edited by Linda Manzanilla, Institute of Anthropological Investigations, Mexico, D.F., Mexico, and approved November 28, 2012 (received for review October 3, 2012)
Descrição: In archaeology, the discovery of ancient medicines is very rare, as is knowledge of their chemical composition. In this paper we present results combining chemical, mineralogical, and botanical investigations on the well-preserved contents of a tin pyxis discovered onboard the Pozzino shipwreck (second century B.C.). The contents consist of six flat, gray, discoid tablets that represent direct evidence of an ancient medicinal preparation. The data revealed extraordinary information on the composition of the tablets and on their possible therapeutic use. Hydrozincite and smithsonite were by far the most abundant ingredients of the Pozzino tablets, along with starch, animal and plant lipids, and pine resin. The composition and the form of the Pozzino tablets seem to indicate that they were used for ophthalmic purposes: the Latin name collyrium (eyewash) comes from the Greek name κoλλυ´ρα , which means “small round loaves.” This study provided valuable information on ancient medical and pharmaceutical practices and on the development of pharmacology and medicine over the centuries. In addition, given the current focus on natural compounds, our data could lead to new investigations and research for therapeutic care.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Ingredients of a 2,000-y-old medicine revealed by chemical, mineralogical, and botanical investigations

Giachi, Gianna ; Pallecchi, Pasquino ; Romualdi, Antonella ; Ribechini, Erika ; Lucejko, Jeannette Jacqueline ; Colombini, Maria Perla ; Lippi, Marta Mariotti

United States: National Academy of Sciences

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