Idioma:

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8⁺ T cells

Weiskopf, Daniela ; Angelo, Michael A ; de Azeredo, Elzinandes L ; Sidney, John ; Greenbaum, Jason A ; Fernando, Anira N ; Broadwater, Anne ; Kolla, Ravi V ; De Silva, Aruna D ; de Silva, Aravinda M ; Mattia, Kimberly A ; Doranz, Benjamin J ; Grey, Howard M ; Shresta, Sujan ; Peters, Bjoern ; Sette, Alessandro

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.E2046-E2053 [Periódico revisado por pares]

United States: National Academy of Sciences

Texto completo disponível

Citações Citado por

Enviar para

Título:
Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8⁺ T cells
Autor: Weiskopf, Daniela ; Angelo, Michael A ; de Azeredo, Elzinandes L ; Sidney, John ; Greenbaum, Jason A ; Fernando, Anira N ; Broadwater, Anne ; Kolla, Ravi V ; De Silva, Aruna D ; de Silva, Aravinda M ; Mattia, Kimberly A ; Doranz, Benjamin J ; Grey, Howard M ; Shresta, Sujan ; Peters, Bjoern ; Sette, Alessandro
Assuntos: Adult ; Biological Sciences ; CD8-Positive T-Lymphocytes - immunology ; Dengue - epidemiology ; Dengue - immunology ; Dengue fever ; Dengue Virus - genetics ; Dengue Virus - immunology ; DNA Primers - genetics ; Enzyme-Linked Immunosorbent Assay ; Enzyme-Linked Immunospot Assay ; Flow Cytometry ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - immunology ; Histocompatibility Antigens Class I - metabolism ; Humans ; Immunologic Memory - immunology ; Monocytes - metabolism ; PNAS Plus ; Polyproteins - immunology ; Polyproteins - metabolism ; Seroepidemiologic Studies ; Sri Lanka - epidemiology ; T cell receptors ; Viruses
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.E2046-E2053
Notas: http://dx.doi.org/10.1073/pnas.1305227110
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Contributed by Howard M. Grey, March 19, 2013 (sent for review January 22, 2013)
Author contributions: D.W., R.V.K., H.M.G., S.S., B.P., and A.S. designed research; D.W., M.A.A., E.L.d.A., J.S., J.A.G., A.N.F., A.B., A.D.D.S., A.M.d.S., K.A.M., B.J.D., and B.P. performed research; A.N.F. and A.D.D.S. contributed new reagents/analytic tools; D.W., M.A.A., E.L.d.A., J.S., J.A.G., A.B., A.M.d.S., K.A.M., B.J.D., H.M.G., B.P., and A.S. analyzed data; and D.W., H.M.G., and A.S. wrote the paper.
Descrição: The role of CD8 ⁺ T cells in dengue virus infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin theory, skewing of T-cell responses induced by primary infection with one serotype causes less effective response upon secondary infection with a different serotype, predisposing individuals to severe disease. A comprehensive analysis of CD8 ⁺ responses in the general population from the Sri Lankan hyperendemic area, involving the measurement of ex vivo IFNγ responses associated with more than 400 epitopes, challenges the original antigenic sin theory. Although skewing of responses toward primary infecting viruses was detected, this was not associated with impairment of responses either qualitatively or quantitatively. Furthermore, we demonstrate higher magnitude and more polyfunctional responses for HLA alleles associated with decreased susceptibility to severe disease, suggesting that a vigorous response by multifunctional CD8 ⁺ T cells is associated with protection from dengue virus disease.
Editor: United States: National Academy of Sciences
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Resultado 1 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8⁺ T cells

United States: National Academy of Sciences

Buscando em bases de dados remotas. Favor aguardar.