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TiF4 Varnish—A 19F-NMR Stability Study and Enamel Reactivity Evaluation

Nóbrega, Carolina Bezerra Cavalcanti ; Fujiwara, Fred Yukio ; Cury, Jaime Aparecido ; Rosalen, Pedro Luiz

Chemical and Pharmaceutical Bulletin, 2008/01/01, Vol.56(1), pp.139-141 [Periódico revisado por pares]

Tokyo: The Pharmaceutical Society of Japan

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  • Título:
    TiF4 Varnish—A 19F-NMR Stability Study and Enamel Reactivity Evaluation
  • Autor: Nóbrega, Carolina Bezerra Cavalcanti ; Fujiwara, Fred Yukio ; Cury, Jaime Aparecido ; Rosalen, Pedro Luiz
  • Assuntos: drug stability ; fluoride varnish ; titanium tetrafluoride
  • É parte de: Chemical and Pharmaceutical Bulletin, 2008/01/01, Vol.56(1), pp.139-141
  • Descrição: The aim of this study was to develop a titanium tetrafluoride (TiF4) varnish and evaluate the stability of the formulation and its reactivity with dental enamel. The varnish was prepared in a resinous matrix using ethanol 96% as solvent. Samples (n=45) were aged at 65 °C and 30% of relativity humidity (RE n° 01/05—ANVISA) and after 3, 6, 9 and 12 months, nine samples were removed for evaluation and compared with fresh samples. Chemical stability of TiF4 varnish was determinate by 19F-NMR and the reactivity of the formulation was quantified by formation of fluoride loosely (CaF2) and firmly bound (fluorapatite; FA) to enamel. For reactivity comparisons, a varnish without TiF4 was used as control. The loss of soluble fluoride was about 0.9% after one year of storage. The values of the reactivity (mean±S.D.) of fresh, aged at 3, 6, 9 and 12 months and control samples were: CaF2 (μg F/mm2): 89.3±27.5a; 54.5±14.3b; 51.2±29.8b; 69.3±21.3a; 48.0±27.4b; 0.10±0.07c, FA (μg F/g): 2477.5±1044.0a; 2484.8±992.0a; 2580.0±1383.9a; 2517.2±929.9a; 2121.0±1059.2a; 330.0±180.0b, respectively. Means followed by distinct letters were statistically different (p<0.05). After one year of storage, the formulation was chemically stable and the levels of FA were maintained. However there was an initial decrease in the ability to form CaF2.
  • Editor: Tokyo: The Pharmaceutical Society of Japan
  • Idioma: Inglês;Japonês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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