Idioma:

Preliminary evaluation of PARACEST MRI agents for the detection of nitric oxide synthase

Suchý, Mojmír ; Li, Alex X ; Liu, Yin ; Feng, Qingping ; Bartha, Robert ; Hudson, Robert H.E

Canadian journal of chemistry, 2016-08, Vol.94 (8), p.715-722 [Periódico revisado por pares]

Ottawa: NRC Research Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Preliminary evaluation of PARACEST MRI agents for the detection of nitric oxide synthase
Autor: Suchý, Mojmír ; Li, Alex X ; Liu, Yin ; Feng, Qingping ; Bartha, Robert ; Hudson, Robert H.E
Assuntos: Amino acids ; arginine ; Chemical properties ; Chemical tests and reagents ; citrulline ; cyclen ; cyclène ; Decoration ; DOTAM ; Dysprosium ; Enzymatic activity ; Enzymes ; IRM ; Magnetic resonance imaging ; MRI ; Nitric oxide ; nitric oxide synthase ; NMR ; Nuclear magnetic resonance ; oxyde nitrique synthase ; PARACEST ; Saturation ; thulium
É parte de: Canadian journal of chemistry, 2016-08, Vol.94 (8), p.715-722
Descrição: Several paramagnetic chemical exchange saturation transfer magnetic resonance imaging (PARACEST MRI) agents for the potential detection of nitric oxide synthase (NOS) have been synthesized and evaluated. These agents are based on an amino acid- or dipeptide-decorated DOTAM (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide) chelator possessing either Tm 3+ or Dy 3+ . The amino acid and dipeptide decorated DOTAMs were designed such that the terminal amino acid pendant group was l -arginine, which may be converted to l -citrulline by NOS. Preliminary evaluation has revealed that some of the l -arginine-decorated complexes are recognized and metabolized by the NOS. Differences in the CEST properties between Dy 3+ -metallated l -arginine- and l -citrulline-modified complexes suggest that these might be suitable for imaging of the NOS enzymatic activity.
Editor: Ottawa: NRC Research Press
Idioma: Inglês

Voltar para lista de resultados

Resultado 1 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Preliminary evaluation of PARACEST MRI agents for the detection of nitric oxide synthase

Suchý, Mojmír ; Li, Alex X ; Liu, Yin ; Feng, Qingping ; Bartha, Robert ; Hudson, Robert H.E

Ottawa: NRC Research Press

Buscando em bases de dados remotas. Favor aguardar.