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Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy

Maspero, J F ; Dueñas-Meza, E ; Volovitz, B ; Pinacho Daza, C ; Kosa, L ; Vrijens, F ; Leff, J A

Current medical research and opinion, 2001-01, Vol.17 (2), p.96-104 [Periódico revisado por pares]

England: Informa Healthcare

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Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy
Autor: Maspero, J F ; Dueñas-Meza, E ; Volovitz, B ; Pinacho Daza, C ; Kosa, L ; Vrijens, F ; Leff, J A
Assuntos: Acetates - administration & dosage ; Acetates - adverse effects ; Acetates - therapeutic use ; Administration, Inhalation ; Administration, Oral ; Adolescent ; Anti-Asthmatic Agents - administration & dosage ; Anti-Asthmatic Agents - adverse effects ; Anti-Asthmatic Agents - therapeutic use ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - adverse effects ; Anti-Inflammatory Agents - therapeutic use ; Asthma - drug therapy ; Asthma - physiopathology ; Beclomethasone - administration & dosage ; Beclomethasone - adverse effects ; Beclomethasone - therapeutic use ; Child ; Cross-Over Studies ; Female ; Forced Expiratory Volume - drug effects ; Health Resources - utilization ; Humans ; Male ; Patient Compliance ; Patient Satisfaction ; Quinolines - administration & dosage ; Quinolines - adverse effects ; Quinolines - therapeutic use ; Time Factors ; Treatment Outcome
É parte de: Current medical research and opinion, 2001-01, Vol.17 (2), p.96-104
Descrição: This 6-month, open-label extension study of a previously described base study compared oral montelukast with inhaled beclomethasone in terms of safety, forced expiratory volume in one second (FEV1) measurements, parent and patient satisfaction with treatment, asthma-related medical resource utilization, school absenteeism, and parental work loss in children with asthma. A total of 124 of 266 asthmatic children, 6 to 11 years of age, who enrolled in the base study entered a 6-month open-label extension study (74 boys, 50 girls) and were re-randomized (2:1 ratio) to receive once-daily oral montelukast (n = 83) or inhaled beclomethasone 100 mcg three times daily (n = 41). Children were evaluated in the clinic prior to re-randomization (Month 0) and at regular visits at 1, 3, and 6 months. Children and their parents showed a significantly higher overall satisfaction for montelukast at 6 months than for inhaled beclomethasone (p = 0.001 and p < 0.05, respectively). According to parents, montelukast was more convenient (p < 0.001), less difficult to use (p = 0.005), and was used as instructed more of the time (p = 0.006) compared with beclomethasone. Oral corticosteroid use was similar in the montelukast (13% of patients) and beclomethasone (17%) treatment groups. The montelukast treatment group was more adherent with their regimen than the inhaled beclomethasone treatment group; almost twice as many children on montelukast compared with inhaled beclomethasone were highly compliant (82% versus 45%). The two study groups were similar with respect to overall safety, change in FEV1, asthma-related medical resource utilization, school absenteeism, and parental work loss. Montelukast represents a safe and effective asthma treatment regimen to which children with asthma are more likely to adhere.
Editor: England: Informa Healthcare
Idioma: Inglês

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Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy

Maspero, J F ; Dueñas-Meza, E ; Volovitz, B ; Pinacho Daza, C ; Kosa, L ; Vrijens, F ; Leff, J A

England: Informa Healthcare

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