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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Caldas, Carlos ; Colomer, Dolors ; Bonaldi, Tiziana ; Lopez, Juan A ; Iyer, N Gopalakrishna ; Calasanz, Maria J ; Pérez-Rosado, Alberto ; Cano, Amparo ; Ahn, Natalie ; Jenuwein, Thomas ; Ropero, Santiago ; Boix-Chornet, Manuel ; Calvo, Enrique ; Haydon, Claire ; Piris, Miguel Ángel ; Esteller, Manel ; Fraga, Mario F ; Villar-Garea, Ana ; Espada, Jesus ; Petrie, Kevin ; Imhof, Axel ; Ballestar, Esteban ; Schotta, Gunnar

Nature genetics, 2005-04, Vol.37 (4), p.391-400 [Periódico revisado por pares]

United States: Nature Publishing Group

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
Autor: Caldas, Carlos ; Colomer, Dolors ; Bonaldi, Tiziana ; Lopez, Juan A ; Iyer, N Gopalakrishna ; Calasanz, Maria J ; Pérez-Rosado, Alberto ; Cano, Amparo ; Ahn, Natalie ; Jenuwein, Thomas ; Ropero, Santiago ; Boix-Chornet, Manuel ; Calvo, Enrique ; Haydon, Claire ; Piris, Miguel Ángel ; Esteller, Manel ; Fraga, Mario F ; Villar-Garea, Ana ; Espada, Jesus ; Petrie, Kevin ; Imhof, Axel ; Ballestar, Esteban ; Schotta, Gunnar
Assuntos: Acetylation ; Cancer ; CpG Islands - genetics ; DNA Methylation ; Epigenetic inheritance ; Gene Expression Regulation, Neoplastic ; Gene Silencing - physiology ; Genetic aspects ; Health aspects ; Histones ; Histones - genetics ; Humans ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Lysine - metabolism ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Promoter Regions, Genetic ; Protein Processing, Post-Translational ; Repetitive Sequences, Nucleic Acid ; Tumor Cells, Cultured
É parte de: Nature genetics, 2005-04, Vol.37 (4), p.391-400
Descrição: CpG island hypermethylation and global genomic hypomethylation are common epigenetic features of cancer cells. Less attention has been focused on histone modifications in cancer cells. We characterized post-translational modifications to histone H4 in a comprehensive panel of normal tissues, cancer cell lines and primary tumors. Using immunodetection, high-performance capillary electrophoresis and mass spectrometry, we found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4. These changes appeared early and accumulated during the tumorigenic process, as we showed in a mouse model of multistage skin carcinogenesis. The losses occurred predominantly at the acetylated Lys16 and trimethylated Lys20 residues of histone H4 and were associated with the hypomethylation of DNA repetitive sequences, a well-known characteristic of cancer cells. Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

United States: Nature Publishing Group

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