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Advancing the understanding of treponemal disease in the past and present

Baker, Brenda J. ; Crane‐Kramer, Gillian ; Dee, Michael W. ; Gregoricka, Lesley A. ; Henneberg, Maciej ; Lee, Christine ; Lukehart, Sheila A. ; Mabey, David C. ; Roberts, Charlotte A. ; Stodder, Ann L. W. ; Stone, Anne C. ; Winingear, Stevie

American journal of physical anthropology, 2020-05, Vol.171 (S70), p.5-41 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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Título:
Advancing the understanding of treponemal disease in the past and present
Autor: Baker, Brenda J. ; Crane‐Kramer, Gillian ; Dee, Michael W. ; Gregoricka, Lesley A. ; Henneberg, Maciej ; Lee, Christine ; Lukehart, Sheila A. ; Mabey, David C. ; Roberts, Charlotte A. ; Stodder, Ann L. W. ; Stone, Anne C. ; Winingear, Stevie
Assuntos: 15th century ; archaeological biogeochemistry ; Archaeology ; archaeometry ; Biological Evolution ; Biology ; Diet ; Environmental conditions ; Epidemiology ; Europe ; genetics ; History, 15th Century ; History, 16th Century ; History, Ancient ; History, Medieval ; Human remains ; human‐pathogen co‐evolution ; Infections ; Interdisciplinary aspects ; Justification ; Lesions ; Medical treatment ; Mercury ; Paleopathology ; Residential mobility ; Rural communities ; Sexually transmitted diseases ; Socioeconomic status ; Socioeconomics ; STD ; Syphilis ; Treponema pallidum ; Treponema pallidum - physiology ; Treponemal Infections - epidemiology ; Treponemal Infections - history ; Treponemal Infections - microbiology ; Understanding ; Vaccines
É parte de: American journal of physical anthropology, 2020-05, Vol.171 (S70), p.5-41
Notas: Funding information
Private Donor, Grant/Award Number: CC0640/GR06564 to Brenda Baker; School for Advanced Research, Grant/Award Number: Research Team Seminar
Descrição: Syphilis was perceived to be a new disease in Europe in the late 15th century, igniting a debate about its origin that continues today in anthropological, historical, and medical circles. We move beyond this age‐old debate using an interdisciplinary approach that tackles broader questions to advance the understanding of treponemal infection (syphilis, yaws, bejel, and pinta). How did the causative organism(s) and humans co‐evolve? How did the related diseases caused by Treponema pallidum emerge in different parts of the world and affect people across both time and space? How are T. pallidum subspecies related to the treponeme causing pinta? The current state of scholarship in specific areas is reviewed with recommendations made to stimulate future work. Understanding treponemal biology, genetic relationships, epidemiology, and clinical manifestations is crucial for vaccine development today and for investigating the distribution of infection in both modern and past populations. Paleopathologists must improve diagnostic criteria and use a standard approach for recording skeletal lesions on archaeological human remains. Adequate contextualization of cultural and environmental conditions is necessary, including site dating and justification for any corrections made for marine or freshwater reservoir effects. Biogeochemical analyses may assess aquatic contributions to diet, physiological changes arising from treponemal disease and its treatments (e.g., mercury), or residential mobility of those affected. Shifting the focus from point of origin to investigating who is affected (e.g., by age/sex or socioeconomic status) and disease distribution (e.g., coastal/ inland, rural/urban) will advance our understanding of the treponemal disease and its impact on people through time.
Editor: Hoboken, USA: John Wiley & Sons, Inc
Idioma: Inglês

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Advancing the understanding of treponemal disease in the past and present

Baker, Brenda J. ; Crane‐Kramer, Gillian ; Dee, Michael W. ; Gregoricka, Lesley A. ; Henneberg, Maciej ; Lee, Christine ; Lukehart, Sheila A. ; Mabey, David C. ; Roberts, Charlotte A. ; Stodder, Ann L. W. ; Stone, Anne C. ; Winingear, Stevie

Hoboken, USA: John Wiley & Sons, Inc

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