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Non-Polar Chemical Constituents of Atemoya and Evaluation of the Cytotoxic and Antimicrobial Activity

Vieira Rab阬o, Suzana ; Granja da Silva Oliveira, Fernanda ; Miriam Calixto de Lira, Michele ; Macedo Dutra, Livia ; Sartoratto, Adilson ; Cristina Teixeira Duarte, Marta ; Claudia dos Santos Luciano, Maria ; Francilene Souza Silva, Maria ; do Pessoa, Cl醬dia ; Odorico de Moraes Filho, Manoel ; Vila鏰 Costa, Emmanoel ; Roberto Guedes da Silva Almeida, Jackson

Phyton (Buenos Aires), 2021, Vol.90 (3), p.921-931

Buenos Aires: Tech Science Press

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Título:
Non-Polar Chemical Constituents of Atemoya and Evaluation of the Cytotoxic and Antimicrobial Activity
Autor: Vieira Rab阬o, Suzana ; Granja da Silva Oliveira, Fernanda ; Miriam Calixto de Lira, Michele ; Macedo Dutra, Livia ; Sartoratto, Adilson ; Cristina Teixeira Duarte, Marta ; Claudia dos Santos Luciano, Maria ; Francilene Souza Silva, Maria ; do Pessoa, Cl醬dia ; Odorico de Moraes Filho, Manoel ; Vila鏰 Costa, Emmanoel ; Roberto Guedes da Silva Almeida, Jackson
Assuntos: Annonaceae ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Bicyclogermacrene ; Chemical composition ; Colon ; Constituents ; Cytotoxicity ; Essential oils ; Gas chromatography ; Glioblastoma ; Leukemia ; Linalool ; Mass spectrometry ; Mass spectroscopy ; Microorganisms ; Monoterpenes ; Ovarian cancer ; Ovarian carcinoma ; Spathulenol ; Toxicity testing ; Tumor cell lines ; α-Pinene
É parte de: Phyton (Buenos Aires), 2021, Vol.90 (3), p.921-931
Descrição: This study aimed to identify the chemical composition of essential oil from fruits (EOAF) and the hexanic crude extract from aerial parts (At-Hex) of atemoya (Annona cherimola x Annona squamosa), a hybrid belonging to the Annonaceae family. Cytotoxic and antimicrobial activity was also evaluated. OEAF was obtained by hydrodistillation using a Clevenger apparatus, and their composition was analyzed by gas chromatography-mass spectrometry (GC-MS) analyses. Cytotoxicity was tested against human tumor cell lines HCT-116 (colon carcinoma), SF-295 (glioblastoma), OVCAR-8 (ovarian carcinoma) and HL60 (leukemia) using 3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2H-tetrazolium bromide (MTT) assay, while antimicrobial activity was conducted by bioauthography method against eleven microorganisms strains. Twenty-four compounds were identified in the EOAF and twenty-nine in At-Hex. The monoterpenes linalool (25.70%), α-pinene (10.38%), β-pinene (9.12%), transocimene (7.43%), and the sesquiterpene bicyclogermacrene (12.58%) were the major constituents of EOAF, whereas the sesquiterpene spathulenol (13.91%) was the main compound of At-Hex. At-Hex showed a high cytotoxicity against SF-295 (glioblastoma). These findings show an important chemotaxonomic contribution for the Annonaceae family, mainly for the Annona genus. Atemoya proved to be a promising source of substances with potential cytotoxic activity.
Editor: Buenos Aires: Tech Science Press
Idioma: Inglês;Francês;Alemão;Italiano;Português;Espanhol

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Non-Polar Chemical Constituents of Atemoya and Evaluation of the Cytotoxic and Antimicrobial Activity

Buenos Aires: Tech Science Press

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