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SCP Phosphatases and Oncogenesis
Puzanov, G. A. ; Senchenko, V. N.
Molecular biology (New York), 2021-07, Vol.55 (4), p.459-469
[Periódico revisado por pares]
Moscow: Pleiades Publishing
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Título:
SCP Phosphatases and Oncogenesis
Autor:
Puzanov, G. A.
;
Senchenko, V. N.
Assuntos:
AKT1 protein
;
Angiogenesis
;
Apoptosis
;
Biochemistry
;
Biomedical and Life Sciences
;
c-Myc protein
;
Carcinogenesis - genetics
;
Cell Cycle
;
Cell Cycle Proteins
;
Cell division
;
Cell Transformation, Neoplastic - genetics
;
Cycle protein
;
Cyclin-dependent kinase
;
Cyclin-dependent kinase inhibitor p21
;
Cyclin-dependent kinases
;
DNA-directed RNA polymerase
;
Enzyme inhibitors
;
Etiology
;
GTP-binding protein
;
Human Genetics
;
Humans
;
Kinases
;
Life Sciences
;
Localization
;
Myc protein
;
Neoplasms - genetics
;
Neuromodulation
;
p53 Protein
;
Phosphatase
;
Phosphoprotein Phosphatases - genetics
;
Promyelocytic leukemia protein
;
Promyeloid leukemia
;
Protein kinase
;
Proteins
;
PTEN protein
;
Reviews
;
RNA polymerase
;
Serine
;
Smad protein
;
Threonine
;
Transcription factors
;
Tumors
É parte de:
Molecular biology (New York), 2021-07, Vol.55 (4), p.459-469
Descrição:
Small SCP phosphatases CTDSP1, CTDSP2, and CTDSPL specifically dephosphorylate serine and threonine residues in protein molecules. The enzymes are involved in regulating activity of RNA polymerase II at the transition from transcription initiation to elongation, regulating expression of neuron-specific genes, and activating the key cell-cycle protein pRb at the G1/S boundary. In addition, the substrates of SCP phosphatases include SMAD transcription modulators; AKT1 protein kinase, which regulates the cell cycle, apoptosis, and angiogenesis; the TWIST1 and c-MYC transcription factors; Rаs family proteins, which are involved in signaling pathways regulating the cell growth and apoptosis; CDCA3, which is associated with cell division; the cyclin-dependent kinase inhibitor p21; and the promyelocytic leukemia protein (PML), which is involved in regulation of the tumor suppressors p53, PTEN, and mTOR. Dysfunction or inactivation of SCP phosphatases leads to various diseases, including cancer. Recently the increase in interest to SCP phosphatases is due to their their tumor growth-inhibiting properties or role in the development of malignant tumors of various etiology and localization. The review discusses the properties of SCP phosphatases and their role in oncogenesis. Understanding the functions of SCP phosphatases and their regulatory mechanisms can be useful in searching for efficient targets for tumor therapy.
Editor:
Moscow: Pleiades Publishing
Idioma:
Inglês;Russo
Links
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