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Extra‐nasal NK/T‐cell lymphoma: A rare case with a rarer presentation

Kumar, Chandan ; Jain, Garima ; Gupta, Anshul ; Pramanik, Raja ; Chopra, Anita

Cytopathology (Oxford), 2022-07, Vol.33 (4), p.518-521 [Peer Reviewed Journal]

England: Wiley Subscription Services, Inc

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Title:
Extra‐nasal NK/T‐cell lymphoma: A rare case with a rarer presentation
Author: Kumar, Chandan ; Jain, Garima ; Gupta, Anshul ; Pramanik, Raja ; Chopra, Anita
Subjects: Aged ; CD45 antigen ; CD56 antigen ; Chromatin ; Cytology ; Cytoplasm ; extra‐nasal NK/T cell lymphoma ; Fever ; Flow Cytometry ; flow‐cytometric immunophenotyping ; Humans ; Immunophenotyping ; Inflammation ; Killer Cells, Natural - pathology ; Lymph Nodes - pathology ; Lymphocytes T ; Lymphoid cells ; Lymphoma ; Lymphoma, Extranodal NK-T-Cell - diagnosis ; Lymphoma, Extranodal NK-T-Cell - pathology ; Lymphoma, T-Cell - diagnosis ; Lymphoma, T-Cell - pathology ; Male ; Nucleoli ; Pleural effusion ; Pleural fluid ; Skin tests ; T-cell lymphoma
Is Part Of: Cytopathology (Oxford), 2022-07, Vol.33 (4), p.518-521
Notes: Funding information
None.
Description: Extra‐nodal (NK/T) cell lymphoma (NKTCL) of nasal type (ENKL) presents with extranodal involvement and is associated with EBV. They are localized primarily to nasal and upper airway region but can rarely involve skin, testis, intestine, muscle, or present as a disseminated disease. We present a case of a 65‐year‐old male presented with bilateral orbital swelling, right parotid swelling, fever, mediastinal nodes, pleural effusion and hepatomegaly. Cytology of pleural fluid showed monomorphic lymphoid cells with folded nuclei, vesicular chromatin, inconspicuous nucleoli and granular cytoplasm. Few histiocytes showing hemophagocytosis were also noted in a background of inflammatory cells. Flow cytometric immunophenotyping of pleural fluid showed abnormal lymphoid cells which were positive for CD45, CD2 and CD56. Histopathological examination of the right eye swelling showed many atypical lymphoid cells which were positive for CD56 and negative for B and T cell markers. Based on morphological and immunophenotypic features a diagnosis of NKTCL, extra‐nasal type was suggested. Patient succumbed to the disease despite aggressive therapy. Extranasal type of NKTCL is an aggressive disease with some characteristic morphological and immunophenotypic features and a poor overall outcome. Pathologists and clinicians must be aware of this entity to ensure a prompt diagnosis and adequate management.
Publisher: England: Wiley Subscription Services, Inc
Language: English

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Extra‐nasal NK/T‐cell lymphoma: A rare case with a rarer presentation

Kumar, Chandan ; Jain, Garima ; Gupta, Anshul ; Pramanik, Raja ; Chopra, Anita

England: Wiley Subscription Services, Inc

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