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Reproductive toxicity of maternal exposure to di(2‐ethylhexyl)phthalate and butyl paraben (alone or in association) on both male and female Wistar offspring

Guerra, Marina Trevizan ; Erthal, Rafaela Pires ; Punhagui‐Umbelino, Ana Paula Franco ; Trinque, Camila Moreira ; Torres de Bari, Maria Antônia ; Nunes, Thamires D'Alexandre Mendonça ; Costa, Wagner Ferrari ; Cleto, Pedro Horácio ; Fernandes, Glaura Scantamburlo Alves

Journal of applied toxicology, 2023-02, Vol.43 (2), p.242-261 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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Título:
Reproductive toxicity of maternal exposure to di(2‐ethylhexyl)phthalate and butyl paraben (alone or in association) on both male and female Wistar offspring
Autor: Guerra, Marina Trevizan ; Erthal, Rafaela Pires ; Punhagui‐Umbelino, Ana Paula Franco ; Trinque, Camila Moreira ; Torres de Bari, Maria Antônia ; Nunes, Thamires D'Alexandre Mendonça ; Costa, Wagner Ferrari ; Cleto, Pedro Horácio ; Fernandes, Glaura Scantamburlo Alves
Assuntos: Animals ; Anogenital ; Body Weight ; Contaminants ; Diethylhexyl Phthalate - toxicity ; Dioctyl phthalate ; Endocrine disruptors ; Endometrium ; Estrogens ; Estrus cycle ; Evaluation ; Female ; Females ; Humans ; Leydig cells ; Male ; Males ; maternal exposure ; Maternal Exposure - adverse effects ; mixture ; Offspring ; Oils & fats ; Organs ; parabens ; Parabens - toxicity ; Phthalates ; Pregnancy ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - pathology ; Puberty ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; reproductive development ; Reproductive organs ; Semen ; Sertoli cells ; Sexual Maturation ; Testis ; Toxicity ; Tubules ; Weight reduction
É parte de: Journal of applied toxicology, 2023-02, Vol.43 (2), p.242-261
Descrição: Parabens and phthalates are commonly found as contaminants in human fluids and are able to provoke reproductive toxicity, being considered endocrine disruptors. To evaluate the effects of phthalate and paraben, alone or in combination, on reproductive development of the offspring, female pregnant Wistar rats were allocated in six experimental groups: Three control groups (gavage [CG], subcutaneous [CS], and gavage + subcutaneous) received corn oil as vehicle, and the remaining groups were exposed to di(2‐ethylhexyl)phthalate (DEHP) (500 mg/kg, gavage), butyl paraben (BP) (100 mg/kg, subcutaneously), or MIX (DEHP + BP), from Gestational Day 12 until Postnatal Day (PND) 21. The following parameters were assessed on the offspring: anogenital distance and weight at PND 1, nipple counting at PND 13, puberty onset, estrous cycle, weights of reproductive and detoxifying organs, histological evaluation of reproductive organs, and sperm evaluations (counts, morphology, and motility). Female pups from MIX group presented reduced body weight at PND 1, lower AGD, and decreased endometrium thickness. Male animals showed decreased body weight at PND 1 and lower number of Sertoli cells on DEHP and MIX groups, MIX group revealed increase of abnormal seminiferous tubules, DEHP animals presented delayed preputial separation and higher percentage of immotile sperms, and BP males presented diminished number of Leydig cells. In conclusion, the male offspring was more susceptible to DEHP toxicity; even when mixed to paraben, the main negative effects observed seem to be due to antiandrogenic phthalate action. On the other hand, DEHP seems to be necessary to improve the effects of BP on reducing estrogen‐dependent and increasing androgen‐dependent events. The effects of phthalate and paraben (considered endocrine disruptors) on reproductive development of the offspring were assessed. Female pregnant Wistar rats were exposed to corn oil (vehicle) or DEHP (500 mg/kg), BP (100 mg/kg), or MIX (DEHP + BP), during gestation and lactation. The male offspring was more susceptible to DEHP toxicity, whereas BP and DEHP in association seem to present more reproductive toxicity in the female pups.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

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Reproductive toxicity of maternal exposure to di(2‐ethylhexyl)phthalate and butyl paraben (alone or in association) on both male and female Wistar offspring

Guerra, Marina Trevizan ; Erthal, Rafaela Pires ; Punhagui‐Umbelino, Ana Paula Franco ; Trinque, Camila Moreira ; Torres de Bari, Maria Antônia ; Nunes, Thamires D'Alexandre Mendonça ; Costa, Wagner Ferrari ; Cleto, Pedro Horácio ; Fernandes, Glaura Scantamburlo Alves

England: Wiley Subscription Services, Inc

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