skip to main content
Language:
Primo Advanced Search
Primo Advanced Search Query Term
Primo Advanced Search Query Term
Primo Advanced Search Query Term
Primo Advanced Search prefilters
Simple Search

Genetic Evidence for a Potentially New Pathogenic Leptospira sp. Circulating in Bats from Brazilian Amazon

Di Azevedo, Maria Isabel Nogueira ; Verde, Rair de Souza ; Ezepha, Camila ; Carvalho-Costa, Filipe Anibal ; D’Andrea, Paulo Sérgio ; Medeiros, Luciana dos Santos ; Lilenbaum, Walter Wu, Zongfu ; Zongfu Wu

Transboundary and emerging diseases, 2023-09, Vol.2023, p.1-11 [Peer Reviewed Journal]

Berlin: Hindawi

Full text available

Citations Cited by
  • Title:
    Genetic Evidence for a Potentially New Pathogenic Leptospira sp. Circulating in Bats from Brazilian Amazon
  • Author: Di Azevedo, Maria Isabel Nogueira ; Verde, Rair de Souza ; Ezepha, Camila ; Carvalho-Costa, Filipe Anibal ; D’Andrea, Paulo Sérgio ; Medeiros, Luciana dos Santos ; Lilenbaum, Walter
  • Wu, Zongfu ; Zongfu Wu
  • Subjects: Animals ; Bats ; Domestic animals ; Ecosystems ; Epidemiology ; Forests ; Haplotypes ; Kidneys ; Leptospira ; Leptospirosis ; Mist ; Molecular chains ; New species ; Phylogenetics ; Phylogeny ; Polymerase chain reaction ; Software ; Spirochetes ; State parks ; Taxonomy ; Urban environments ; Vigilance ; Wild animals
  • Is Part Of: Transboundary and emerging diseases, 2023-09, Vol.2023, p.1-11
  • Description: Leptospirosis is a neglected zoonosis frequently reported worldwide, caused by a spirochete of the genus Leptospira. It is capable of infecting domestic animals, free-living animals, and humans. Among wild animals, the role of bats in the epidemiology of leptospirosis has been investigated but is far from being elucidated. The Amazonian biome has the ideal conditions for maintaining and disseminating leptospires and, despite efforts that have been made to better understand leptospires’ occurrence in wild animals in the region, few studies aimed to explore and genetically characterize leptospires in bats. Based on this, the aim of the present study is to deeper investigate and genetically characterize leptospires detected in bats from the southwest Amazon. Animals were trapped by mist netting at five sites in the state of Acre, Brazil. Kidney samples were obtained and stored for molecular analysis. Polymerase chain reaction (PCR) was conducted first based on the LipL32 gene, and positive samples were submitted to rrs and secY-PCR and sequencing. Sequences were then submitted to phylogenetic analyses through multiple bioinformatic tools. The rrs sequences from the present study formed one single haplotype, different from any other previously deposited, grouped in a highly supported cluster with sequences from bats from Madagascar and China. The initial secY screening revealed no identity with previously deposited sequences. The phylogenetic trees revealed the sequences from the present study in an isolated branch, clearly separated from all previously known pathogenic Leptospira spp., suggesting the existence of a potentially undescribed species. The haplotype network including only leptospires from the Amazon region confirmed two new haplotypes from the same taxon unity, isolated from the others, with a probable origin of the species from L. noguchii. The characterization of this potentially new species in bats reinforces the complexity of the transmission dynamics of leptospires, including wild, periurban, and urban environments, emphasizing the need for an integrative look at leptospirosis vigilance within the context of One Health.
  • Publisher: Berlin: Hindawi
  • Language: English;German
Back to results list
Go to Previous pagePrevious Result  3 NextGo to Next page

  • Implemented by: ABCD-USP USP   Social Network Logos: Freepik

Searching Remote Databases, Please Wait

  • Searching for
  • inscope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
  • Show me what you have so far