Idioma:

NAPROXEN/LAYERED DOUBLE HYDROXIDE COMPOSITES FOR TISSUE-ENGINEERING APPLICATIONS: PHYSICOCHEMICAL CHARACTERIZATION AND BIOLOGICAL EVALUATION

Bernardo, Marcela P. ; Rodrigues, Bruna C.S. ; de Oliveira, Tamires D. ; Guedes, Adriana P.M. ; Batista, Alzir A. ; Mattoso, Luiz H.C.

Clays and clay minerals, 2020-12, Vol.68 (6), p.623-631 [Periódico revisado por pares]

Cham: Springer International Publishing

Texto completo disponível

Citações Citado por

Enviar para

Título:
NAPROXEN/LAYERED DOUBLE HYDROXIDE COMPOSITES FOR TISSUE-ENGINEERING APPLICATIONS: PHYSICOCHEMICAL CHARACTERIZATION AND BIOLOGICAL EVALUATION
Autor: Bernardo, Marcela P. ; Rodrigues, Bruna C.S. ; de Oliveira, Tamires D. ; Guedes, Adriana P.M. ; Batista, Alzir A. ; Mattoso, Luiz H.C.
Assuntos: Aluminum ; Anti-inflammatory agents ; Aqueous solutions ; Biocompatibility ; Biogeosciences ; Biomaterials ; Biomedical materials ; Bone biomaterials ; Bone grafts ; Bone growth ; Bones ; Controlled release ; Cytology ; Cytotoxicity ; Drug delivery ; Drugs ; Earth and Environmental Science ; Earth Sciences ; Geochemistry ; Grafts ; Hydroxides ; Immunosuppressive agents ; Inflammation ; Interlayers ; Kinetics ; Magnesium ; Medicinal Chemistry ; Mineralogy ; Nanoscale Science and Technology ; Naproxen ; NMR ; Nonsteroidal anti-inflammatory drugs ; Nuclear magnetic resonance ; Pain ; Regeneration ; Regeneration (biological) ; Regeneration (physiology) ; Skin & tissue grafts ; Sodium ; Soil Science & Conservation ; Substitute bone ; Tissue engineering
É parte de: Clays and clay minerals, 2020-12, Vol.68 (6), p.623-631
Descrição: Injured bone tissues can be healed with bone grafts, but this procedure may cause intense pain to the patient. A slow and localized delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) could help to reduce the pain without affecting bone regeneration. The objective of the present study was to use [Mg-Al]-layered double hydroxide (LDH) as a matrix for controlled release of sodium naproxen (NAP). This system could be applied in biomaterial formulations (such as bone grafts) to achieve a local delivery of naproxen. [Mg-Al]-LDH successfully incorporated up to 80% (w/w) of naproxen by the structural reconstruction route, with the [Mg-Al]-LDH interlayer space increasing by 0.55 nm, corresponding to the drug molecule size. The evaluation of the naproxen release kinetics showed that 40% of the drug was delivered over 48 h in aqueous medium (pH 7.4 ± 0.1), indicating the potential of [Mg-Al]-LDH/NAP for local release of naproxen at adequate concentrations. Kinetic modeling showed that the naproxen release process was closely related to the Higuchi model, which considers the drug release as a diffusional process based on Fick’s law. The chemical stability of NAP after the release tests was verified by 1 H NMR. The [Mg-Al]-LDH/NAP also exhibited low cytotoxicity toward fibroblast cells (L929 cell line), without modifications in their morphology and adhesion capacity. These results describe a suitable approach for preparing efficient systems for local delivery of nonsteroidal anti-inflammatory drugs for biomedical applications.
Editor: Cham: Springer International Publishing
Idioma: Inglês

Voltar para lista de resultados

Anterior Resultado 2 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

NAPROXEN/LAYERED DOUBLE HYDROXIDE COMPOSITES FOR TISSUE-ENGINEERING APPLICATIONS: PHYSICOCHEMICAL CHARACTERIZATION AND BIOLOGICAL EVALUATION

Bernardo, Marcela P. ; Rodrigues, Bruna C.S. ; de Oliveira, Tamires D. ; Guedes, Adriana P.M. ; Batista, Alzir A. ; Mattoso, Luiz H.C.

Cham: Springer International Publishing

Buscando em bases de dados remotas. Favor aguardar.