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Test for CCR5 tropism and treatment with maraviroc in Sicily: an observational retrospective multicentre study

Celesia, B ; Gussio, M ; Franco, A ; Scifo, G ; Prestileo, T ; Di Lorenzo, F ; La Rosa, R ; Nigro, L ; Colomba, C ; Ingrassia, D ; Galvagna, S ; Mannino, G ; Storaci, N ; Migliore, S ; Salvo, A ; Todaro, G ; Portelli, V ; Sturniolo, G ; Davi’, A ; Bruno, S ; Bellissima, P ; Guarneri, L ; Palermo, F ; Zagami, A ; Nunnari, G ; Cosentino, S

Journal of the International AIDS Society, 2012-11, Vol.15 (S4), p.1-1 [Periódico revisado por pares]

Geneva: International AIDS Society

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  • Título:
    Test for CCR5 tropism and treatment with maraviroc in Sicily: an observational retrospective multicentre study
  • Autor: Celesia, B ; Gussio, M ; Franco, A ; Scifo, G ; Prestileo, T ; Di Lorenzo, F ; La Rosa, R ; Nigro, L ; Colomba, C ; Ingrassia, D ; Galvagna, S ; Mannino, G ; Storaci, N ; Migliore, S ; Salvo, A ; Todaro, G ; Portelli, V ; Sturniolo, G ; Davi’, A ; Bruno, S ; Bellissima, P ; Guarneri, L ; Palermo, F ; Zagami, A ; Nunnari, G ; Cosentino, S
  • Assuntos: Acquired immune deficiency syndrome ; AIDS ; Antiretroviral drugs ; Infectious diseases ; Proteinase inhibitors ; Ritonavir ; Sexually transmitted diseases ; STD
  • É parte de: Journal of the International AIDS Society, 2012-11, Vol.15 (S4), p.1-1
  • Descrição: Purpose of the study Maraviroc (MVC) is the first CCR5 inhibitor licensed for clinical use. A pre‐treatment test is mandatory to identify R5 tropic patients. Aim of this study is to detect indications and results of tropism test and to evaluate efficacy and tolerability of MVC‐based regimen. Methods An observational retrospective multicentre study was performed in Sicily in 15 Infectious Diseases Units. Clinical records of 213 screened for tropism HIV+ subjects were reviewed for age, sex, risk, clinical stage (CDC, CD4 cell count, HIV RNA viral load), therapeutic line, indication and result of test for tropism; within subjects treated with MVC, HIV RNA, CD4 cell count and metabolic parameters trend and adverse events were analysed. Summary of results Median age 44 (IQR 30–50) years, 67.1% males; 46.3% heterosexuals, 28.6% MSMs, 21.4% IVDUs; 23.7% CDC A, 32.1% CDC B, 44.2% CDC C; median CD4 was 217 (IQR 121–374) cells/µl and mean of HIV RNA was 4.72 (Cl 95% 4.07–4.67) log10 copies/ml; median therapeutic line was 4 (IQR 2–7). 80.8% were submitted to Trofile™ test, 19.2% to genotypic test, 75.5% after a therapeutic failure. 56.8% of subjects screened were R5, 7.5% X4, 21.6% DM, 14% undefined. All X4 patients were tested after a therapeutic failure; patients screened for toxicity were more frequently R5 (75%) (p<0.01). 76 (35.7%) multi‐experienced (at baseline 8% HIV RNA<50 copies/ml, median CD4 cell count 219 (IQR 124–345) cells/µl) subjects were treated with MVC plus an optimized background treatment: MVC was associated in 74% of cases with a protease inhibitors (56% darunavir/ritonavir), in 42% with raltegravir, in 56% with a NUC‐sparing regimen. After 12 months of treatment 56.8% (ITT analysis) and 61.7% (AT) of patients had HIV RNA<50 copies/ml; median CD4 cell count was 387 (IQR 222–455) cells/µl. After 24 months 64.8% (ITT) 80% (AT) had HIV‐RNA<50 copies/ml. Median CD4 cell count was 381 (IQR 218.515) cells/µl with a median increase of 168 (IQR 54–274) cells/µl. At 24 months median value of total and HDL cholesterol and triglycerides were within the normal range. 7 patients stopped the treatment: 2 died, 1 adverse event, 4 virological failure. Conclusions Although the test has been proposed to patients with long treatment history and failure, only 3/5 of R5 tropic patients were treated with MVC. An high number of multi‐experienced subjects treated with a MVC‐based regimen obtained HIV RNA<50 copies/ml and a satisfactory increase of CD4 cell count.
  • Editor: Geneva: International AIDS Society
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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