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Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature

Hiramatsu, Keiichi ; Igarashi, Masayuki ; Morimoto, Yuh ; Baba, Tadashi ; Umekita, Maya ; Akamatsu, Yuzuru

International journal of antimicrobial agents, 2012-06, Vol.39 (6), p.478-485 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
Autor: Hiramatsu, Keiichi ; Igarashi, Masayuki ; Morimoto, Yuh ; Baba, Tadashi ; Umekita, Maya ; Akamatsu, Yuzuru
Assuntos: Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; DNA Gyrase - genetics ; Drug Resistance, Bacterial - drug effects ; gyrA mutations ; Humans ; Infectious Disease ; Medical sciences ; Methicillin - pharmacology ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - genetics ; Microbial Sensitivity Tests ; Mutation ; Nybomycin ; Pharmacology. Drug treatments ; Quinolone resistance ; Quinolones - pharmacology ; Reverse antibiotic ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Vancomycin - pharmacology ; Vancomycin Resistance - drug effects ; VISA ; VRSA
É parte de: International journal of antimicrobial agents, 2012-06, Vol.39 (6), p.478-485
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: Abstract By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu50. The mutants, occurring at an extremely low rate (<1 × 10−11 /generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated ‘reverse antibiotics’.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature

Hiramatsu, Keiichi ; Igarashi, Masayuki ; Morimoto, Yuh ; Baba, Tadashi ; Umekita, Maya ; Akamatsu, Yuzuru

Amsterdam: Elsevier B.V

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