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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Ge, Dongliang ; Thompson, Alexander J ; Bertelsen, Arthur H ; Goldstein, David B ; Heinzen, Erin L ; McHutchison, John G ; Simon, Jason S ; Shianna, Kevin V ; Qiu, Ping ; Sulkowski, Mark ; Fellay, Jacques ; Muir, Andrew J ; Urban, Thomas J

Nature (London), 2009-09, Vol.461 (7262), p.399-401 [Periódico revisado por pares]

London: Nature Publishing Group

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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Autor: Ge, Dongliang ; Thompson, Alexander J ; Bertelsen, Arthur H ; Goldstein, David B ; Heinzen, Erin L ; McHutchison, John G ; Simon, Jason S ; Shianna, Kevin V ; Qiu, Ping ; Sulkowski, Mark ; Fellay, Jacques ; Muir, Andrew J ; Urban, Thomas J
Assuntos: African Americans ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Asia, Eastern - ethnology ; Biological and medical sciences ; Black or African American - genetics ; Chromosomes, Human, Pair 19 - genetics ; Clinical Trials as Topic ; Confidence intervals ; Demographic aspects ; Development and progression ; Drug therapy ; Europe - ethnology ; Gene expression ; Gene Frequency ; Genetic aspects ; Genetic polymorphisms ; Genetic Variation - genetics ; Genome, Human - genetics ; Genome-Wide Association Study ; Genotype ; Hepacivirus - drug effects ; Hepatitis ; Hepatitis C ; Hepatitis C virus ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - ethnology ; Hepatitis C, Chronic - genetics ; Hepatitis C, Chronic - virology ; Hispanic or Latino - genetics ; HIV ; Human immunodeficiency virus ; Humans ; Identification and classification ; Infections ; Interferon alpha-2 ; Interferon-alpha - adverse effects ; Interferon-alpha - pharmacology ; Interferon-alpha - therapeutic use ; Interferons ; Interleukins - genetics ; Medical sciences ; Minority & ethnic groups ; Pharmacogenetics ; Pharmacology. Drug treatments ; Polyethylene Glycols - adverse effects ; Polyethylene Glycols - pharmacology ; Polyethylene Glycols - therapeutic use ; Polymorphism, Single Nucleotide - genetics ; Recombinant Proteins ; Viral Load
É parte de: Nature (London), 2009-09, Vol.461 (7262), p.399-401
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon- -2b (PegIFN- -2b) or - -2a (PegIFN- -2a) combined with ribavirin (RBV), it is well known that many patients will not be cured by treatment, and that patients of European ancestry have a significantly higher probability of being cured than patients of African ancestry. In addition to limited efficacy, treatment is often poorly tolerated because of side effects that prevent some patients from completing therapy. For these reasons, identification of the determinants of response to treatment is a high priority. Here we report that a genetic polymorphism near the IL28B gene, encoding interferon- -3 (IFN- -3), is associated with an approximately twofold change in response to treatment, both among patients of European ancestry (P = 1.06 × 10-25) and African-Americans (P = 2.06 × 10-3). Because the genotype leading to better response is in substantially greater frequency in European than African populations, this genetic polymorphism also explains approximately half of the difference in response rates between African-Americans and patients of European ancestry.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Ge, Dongliang ; Thompson, Alexander J ; Bertelsen, Arthur H ; Goldstein, David B ; Heinzen, Erin L ; McHutchison, John G ; Simon, Jason S ; Shianna, Kevin V ; Qiu, Ping ; Sulkowski, Mark ; Fellay, Jacques ; Muir, Andrew J ; Urban, Thomas J

London: Nature Publishing Group

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