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Polyomavirus-induced pilomatricomas in mice: from viral inoculation to tumour development

SÍMULA, SILVINA ; OZUNA, PAOLA VILLÁN ; OTERO, JAVIER ; CASAS, JOSÉ ; SANJUAN, NORBERTO

APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2012-05, Vol.120 (5), p.397-404 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Polyomavirus-induced pilomatricomas in mice: from viral inoculation to tumour development
Autor: SÍMULA, SILVINA ; OZUNA, PAOLA VILLÁN ; OTERO, JAVIER ; CASAS, JOSÉ ; SANJUAN, NORBERTO
Assuntos: Animals ; Animals, Newborn ; Biological and medical sciences ; Blood ; Blotting, Western ; Cell Proliferation ; Development ; Disease Progression ; Female ; Fluorescent Antibody Technique, Indirect ; Follicles ; Fundamental and applied biological sciences. Psychology ; Hair ; Hair Diseases - pathology ; Hair Diseases - virology ; hair follicle ; Hair loss ; Immunization ; Infection ; Infectious diseases ; Inoculation ; Keratin ; Male ; Medical sciences ; Mice ; Mice, Inbred C3H ; Microbiology ; Microscopy, Electron, Transmission ; Miscellaneous ; Neonates ; NIH 3T3 Cells ; Nuclei ; oncogenesis ; pilomatricoma ; Pilomatrixoma - pathology ; Pilomatrixoma - ultrastructure ; Pilomatrixoma - virology ; Polyoma ; Polyomavirus ; Polyomavirus - physiology ; Polyomavirus Infections - pathology ; Polyomavirus Infections - virology ; Sheaths ; Skin ; Skin Neoplasms - pathology ; Skin Neoplasms - ultrastructure ; Skin Neoplasms - virology ; Tumors ; Virology ; Virus Replication
É parte de: APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2012-05, Vol.120 (5), p.397-404
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Descrição: Símula S,Villán Ozuna P, Otero J, Casas J, Sanjuan N. Polyomavirus‐induced pilomatricomas in mice: From viral inoculation to tumour development. APMIS 2012; 120: 397–404. Polyomavirus has been used extensively to study tumour induction in mice. Although most neoplasms are well characterized, those arising from hair follicles have been referred to by different names during the last four decades. The purpose of this research was to contribute to a more accurate histological characterization of these tumours as well as to study the viral progression from the onset of infection to the development of neoplasms. Polyomavirus A2 was inoculated into newborn C3H/BiDa mice, and at different time‐points (from 5 to 70 days post‐inoculation) the mice were sacrificed and studied using histological, immunocytochemical, ultrastructural and virological methods. The fully developed hair follicle tumours consisted of a proliferation of matrix cells that evolved into ‘shadow’ cells with empty nuclei and finally into amorphous keratin; the tumours were therefore diagnosed as pilomatricomas. Viral VP‐1 was observed only in fully differentiated cells and not in proliferating‐cell‐nuclear‐antigen (PCNA)‐positive cells in the same tumour. In conclusion, Polyomavirus first replicated in the skin, and then disseminated through the blood and reached the outer sheath of the hair follicles and finally infected matrix cells, leading to the development of pilomatricomas from which infectious virus was isolated.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Polyomavirus-induced pilomatricomas in mice: from viral inoculation to tumour development

SÍMULA, SILVINA ; OZUNA, PAOLA VILLÁN ; OTERO, JAVIER ; CASAS, JOSÉ ; SANJUAN, NORBERTO

Oxford, UK: Blackwell Publishing Ltd

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