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Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F ; Liberal, J.T ; Baptista, F.I ; Gaspar, J.M ; Carvalho, A.L ; Ambrósio, A.F

Neuroscience, 2012-09, Vol.219, p.23-32 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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Título:
Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus
Autor: Castilho, A.F ; Liberal, J.T ; Baptista, F.I ; Gaspar, J.M ; Carvalho, A.L ; Ambrósio, A.F
Assuntos: AMPA receptors ; Animals ; Biological and medical sciences ; Blotting, Western ; Diabetes Mellitus, Experimental - metabolism ; Diabetes. Impaired glucose tolerance ; diabetic encephalopathy ; diabetic retinopathy ; elevated glucose ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Glucose ; Hippocampus - metabolism ; Hyperglycemia - metabolism ; Immunohistochemistry ; Medical sciences ; Neurology ; Neurons - metabolism ; Rats ; Rats, Wistar ; Receptors, AMPA - metabolism ; Retina - metabolism ; Vertebrates: nervous system and sense organs
É parte de: Neuroscience, 2012-09, Vol.219, p.23-32
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Highlights ► Elevated glucose increases GluA2 levels in retinal neural cells. ► Elevated glucose increases AMPAR at the plasma membrane in retinal neural cells. ► AMPAR content is not altered by elevated glucose in hippocampal neurons. ► AMPAR are more susceptible to elevated glucose in retinal than hippocampal neurons.
Editor: Amsterdam: Elsevier Ltd
Idioma: Inglês

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Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F ; Liberal, J.T ; Baptista, F.I ; Gaspar, J.M ; Carvalho, A.L ; Ambrósio, A.F

Amsterdam: Elsevier Ltd

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