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Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results

Lopes, Renato D., MD, PhD ; Williams, Judson B., MD ; Mehta, Rajendra H., MD, MS ; Reyes, Eric M., MS ; Hafley, Gail E., MS ; Allen, Keith B., MD ; Mack, Michael J., MD ; Peterson, Eric D., MD, MPH ; Harrington, Robert A., MD ; Gibson, C. Michael, MD ; Califf, Robert M., MD ; Kouchoukos, Nicholas T., MD ; Ferguson, T. Bruce, MD ; Lorenz, Todd J., MD ; Alexander, John H., MD, MHS

The American heart journal, 2012-09, Vol.164 (3), p.379-386.e1 [Periódico revisado por pares]

New York, NY: Mosby, Inc

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Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results
Autor: Lopes, Renato D., MD, PhD ; Williams, Judson B., MD ; Mehta, Rajendra H., MD, MS ; Reyes, Eric M., MS ; Hafley, Gail E., MS ; Allen, Keith B., MD ; Mack, Michael J., MD ; Peterson, Eric D., MD, MPH ; Harrington, Robert A., MD ; Gibson, C. Michael, MD ; Califf, Robert M., MD ; Kouchoukos, Nicholas T., MD ; Ferguson, T. Bruce, MD ; Lorenz, Todd J., MD ; Alexander, John H., MD, MHS
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Clinical outcomes ; Combined Modality Therapy ; Coronary Artery Bypass ; Coronary Artery Disease - drug therapy ; Coronary Artery Disease - mortality ; Coronary Artery Disease - surgery ; Coronary heart disease ; Coronary vessels ; Double-Blind Method ; Follow-Up Studies ; Heart ; Heart attacks ; Humans ; Kaplan-Meier Estimate ; Medical sciences ; Middle Aged ; Myocardial Infarction - epidemiology ; Myocardial Revascularization - statistics & numerical data ; Older people ; Oligonucleotides - therapeutic use ; Patient Readmission - statistics & numerical data ; Postoperative Complications ; Proportional Hazards Models ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Treatment Outcome ; Young Adult
É parte de: The American heart journal, 2012-09, Vol.164 (3), p.379-386.e1
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
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Descrição: Background Edifoligide, an E2F transcription factor decoy, does not prevent vein graft failure or adverse clinical outcomes at 1 year in patients undergoing coronary artery bypass grafting (CABG). We compared the 5-year clinical outcomes of patients in PREVENT IV treated with edifoligide and placebo to identify predictors of long-term clinical outcomes. Methods A total of 3,014 patients undergoing CABG with at least 2 planned vein grafts were enrolled. Kaplan-Meier curves were generated to compare the long-term effects of edifoligide and placebo. A Cox proportional hazards model was constructed to identify factors associated with 5-year post-CABG outcomes. The main outcome measures were death, myocardial infarction (MI), repeat revascularization, and rehospitalization through 5 years. Results Five-year follow-up was complete in 2,865 patients (95.1%). At 5 years, patients randomized to edifoligide and placebo had similar rates of death (11.7% and 10.7%, respectively), MI (2.3% and 3.2%), revascularization (14.1% and 13.9%), and rehospitalization (61.6% and 62.5%). The composite outcome of death, MI, or revascularization occurred at similar frequency in patients assigned to edifoligide and placebo (26.3% and 25.5%, respectively; hazard ratio 1.03 [95% CI 0.89-1.18], P = .721). Factors associated with death, MI, or revascularization at 5 years included peripheral and/or cerebrovascular disease, time on cardiopulmonary bypass, lung disease, diabetes mellitus, and congestive heart failure. Conclusions Up to a quarter of patients undergoing CABG will have a major cardiac event or repeat revascularization procedure within 5 years of surgery. Edifoligide does not affect outcomes after CABG; however, common identifiable baseline and procedural risk factors are associated with long-term outcomes after CABG.
Editor: New York, NY: Mosby, Inc
Idioma: Inglês

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Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results

New York, NY: Mosby, Inc

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