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SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago)

Ubillas, R. ; Jolad, S.D. ; Bruening, R.C. ; Kernan, M.R. ; King, S.R. ; Sesin, D.F. ; Barrett, M. ; Stoddart, C.A. ; Flaster, T. ; Kuo, J. ; Ayala, F. ; Meza, E. ; Castañel, M. ; Mcmeekin, D. ; Rozhon, E. ; Tempesta, M.S. ; Barnard, D. ; Huffman, J. ; Smee, D. ; Sidwell, R. ; Soike, K. ; Brazier, A. ; Safrin, S. ; Orlando, R. ; Kenny, P.T.M. ; Berova, N. ; Nakanishi, K.

Phytomedicine (Stuttgart), 1994-09, Vol.1 (2), p.77-106 [Periódico revisado por pares]

Germany: Elsevier GmbH

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  • Título:
    SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago)
  • Autor: Ubillas, R. ; Jolad, S.D. ; Bruening, R.C. ; Kernan, M.R. ; King, S.R. ; Sesin, D.F. ; Barrett, M. ; Stoddart, C.A. ; Flaster, T. ; Kuo, J. ; Ayala, F. ; Meza, E. ; Castañel, M. ; Mcmeekin, D. ; Rozhon, E. ; Tempesta, M.S. ; Barnard, D. ; Huffman, J. ; Smee, D. ; Sidwell, R. ; Soike, K. ; Brazier, A. ; Safrin, S. ; Orlando, R. ; Kenny, P.T.M. ; Berova, N. ; Nakanishi, K.
  • Assuntos: antiviral activity ; Croton lechleri (sangre de drago) ; oligomeric procyanidin SP-303
  • É parte de: Phytomedicine (Stuttgart), 1994-09, Vol.1 (2), p.77-106
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: SP-303, a large proanthocyanidin oligomer isolated from the latex of the plant species Croton lechleri (Eupborbiaceae) has demonstrated broad activity against a variety of DNA and RNA viruses. In cell culture, SP-303 exhibits potent activity against isolates and laboratory strains of respiratory syncytial virus (RSV), influenza A virus (FLU-A) and parainfluenza virus (PIV). Parallel assays of SP-303 and ribavirin showed comparable activity against these viruses. SP-303 also exhibits significant inhibitory activity against herpesvirus (HSV) types 1 and 2, including herpesviruses resistant to acyclovir and foscarnet. Inhibition was also observed against hepatitis A and B viruses. The antiviral mechanism of SP-303 seems to derive from its direct binding to components of the viral envelope, resulting in inhibition of viral attachment and penetration of the plasma membrane. Antiviral effects of SP-303 were measured by three distinct methods: CPE, MTT and precursor uptake/incorporation. Cytotoxicity endpoints were markedly greater than the respective antiviral endpoints. SP-303 exhibited activity in RSV-infected cotton rats and African green monkeys, PIV-3-infected cotton rats, HSV-2 infected mice and guinea pigs and FLU-A-infected mice. The most successful routes of SP-303 administration for producing efficacy were: topical application to HSV-2- genital lesions in mice and guinea pigs, aerosol inhalation to FLU-A-infected mice and PIV-3-infected cotton rats, and oral dosage to RSV-infected cotton rats. A variety of toxicological evaluations demonstrated the safety of SP-303, particularly orally, which was predictable, since condensed tannins are a common dietary component. It is notable that the larger proanthocyanidins as a class have high antiviral activity, whereas most of the monomers are inactive. Clinical trials are ongoing to evaluate SP-303 as a therapeutic antiviral agent.
  • Editor: Germany: Elsevier GmbH
  • Idioma: Inglês
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