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Cellular immune reactions in the lung

Hasenberg, Mike ; Stegemann-Koniszewski, Sabine ; Gunzer, Matthias

Immunological reviews, 2013-01, Vol.251 (1), p.189-214 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Cellular immune reactions in the lung
Autor: Hasenberg, Mike ; Stegemann-Koniszewski, Sabine ; Gunzer, Matthias
Assuntos: Adaptive Immunity ; Alveoli ; Animals ; dendritic cells ; Environmental Exposure ; fungal infection ; Gas exchange ; Homeostasis ; Humans ; Immune system ; Immunity, Cellular ; Immunity, Innate ; Infection ; Lung ; Lung - immunology ; Microorganisms ; Mycoses - immunology ; neutrophils ; phagocytosis ; Polarization ; Respiratory Mucosa - immunology ; Respiratory system ; Respiratory tract ; Reviews ; Surfactants ; viral infection ; Virus Diseases - immunology
É parte de: Immunological reviews, 2013-01, Vol.251 (1), p.189-214
Notas: ark:/67375/WNG-19T2B681-G
istex:05C71C3247FA7E63CB02E7CCE154481BF5650A09
German Research Foundation - No. GU769/4-1; No. SPP1468; No. GU769/5-1; No. BR2221/1-1
ArticleID:IMR12020
These authors contributed equally
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Summary The lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, complex structures and mechanisms have evolved to recognize and fend off environmental dangers while at the same time allowing efficient gas exchange. Here we review our current knowledge regarding cellular mechanisms of the immune system in context with the highly specialized anatomical features of the airways and especially the alveolar compartment. The focus is on fungal and viral infections, merging anatomical aspects well known to pulmonologists with fundamental immunological concepts. We discuss the specialized morphological constraints of immune cells compressed under a continuous layer of the surfactant lining within alveoli as well as the importance of functional polarization of respiratory tract epithelia. Furthermore, we summarize the different types of innate and adaptive immune cells and their relative contribution to lung homeostasis with respect to localization. Finally, we provide a list of currently unresolved questions with high relevance for the field that might serve as food for thought regarding future research directions.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Cellular immune reactions in the lung

Hasenberg, Mike ; Stegemann-Koniszewski, Sabine ; Gunzer, Matthias

England: Blackwell Publishing Ltd

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