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Distribution of Blood–Brain Barrier Disruption in Primary Blast Injury

Yeoh, Stewart ; Bell, E. David ; Monson, Kenneth L.

Annals of biomedical engineering, 2013-10, Vol.41 (10), p.2206-2214 [Revista revisada por pares]

Boston: Springer US

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Título:
Distribution of Blood–Brain Barrier Disruption in Primary Blast Injury
Autor: Yeoh, Stewart ; Bell, E. David ; Monson, Kenneth L.
Materias: Animals ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Blast Injuries - pathology ; Blast Injuries - physiopathology ; Blood-Brain Barrier - pathology ; Blood-Brain Barrier - physiopathology ; Brain Injuries - pathology ; Brain Injuries - physiopathology ; Classical Mechanics ; Explosions ; Humans ; Rats ; Rats, Sprague-Dawley
Es parte de: Annals of biomedical engineering, 2013-10, Vol.41 (10), p.2206-2214
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Traumatic brain injury (TBI) resulting from explosive-related blast overpressure is a topic at the forefront of neurotrauma research. Compromise of the blood–brain barrier (BBB) and other cerebral blood vessel dysfunction is commonly reported in both experimental and clinical studies on blast injury. This study used a rifle primer-driven shock tube to investigate cerebrovascular injury in rats exposed to low-impulse, pure primary blast at three levels of overpressure (145, 232, and 323 kPa) and with three survival times (acute, 24, and 48 h). BBB disruption was quantified immunohistochemically by measuring immunoglobulin G (IgG) extravasation with image analysis techniques. Pure primary blast generated small lesions scattered throughout the brain. The number and size of lesions increased with peak overpressure level, but no significant difference was seen between survival times. Despite laterally directed blast exposure, equal numbers of lesions were found in each hemisphere of the brain. These observations suggest that cerebrovascular injury due to primary blast is distinct from that associated with conventional TBI.
Editor: Boston: Springer US
Idioma: Inglés

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Distribution of Blood–Brain Barrier Disruption in Primary Blast Injury

Yeoh, Stewart ; Bell, E. David ; Monson, Kenneth L.

Boston: Springer US

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