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Population genetics of insertion–deletion polymorphisms in South Koreans using Investigator DIPplex kit

Seong, Ki Min ; Park, Ji Hye ; Hyun, Young Se ; Kang, Pil Won ; Choi, Dong Ho ; Han, Myun Soo ; Park, Ki Won ; Chung, Ki Wha

Forensic science international : genetics, 2014-01, Vol.8 (1), p.80-83 [Periódico revisado por pares]

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Título:
Population genetics of insertion–deletion polymorphisms in South Koreans using Investigator DIPplex kit
Autor: Seong, Ki Min ; Park, Ji Hye ; Hyun, Young Se ; Kang, Pil Won ; Choi, Dong Ho ; Han, Myun Soo ; Park, Ki Won ; Chung, Ki Wha
Assuntos: Base Sequence ; DNA Primers ; Genetics, Population ; Humans ; Pathology ; Polymorphism, Genetic ; Republic of Korea
É parte de: Forensic science international : genetics, 2014-01, Vol.8 (1), p.80-83
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract We assessed the applicability of 30 insertion–deletion polymorphisms (INDELs) in forensic use and the level of genetic diversity in South Korea ( n = 373) using the Investigator DIPplex® kit (Qiagen). Allele frequencies, heterozygocities, and forensic efficacy parameters were determined. No deviation from Hardy–Weinberg equilibrium was observed for any of the INDEL markers. A high level of discrimination power was observed (combined power of discrimination: 0.99999999995). The combined match probability value was 2.84 × 10−11 and the mean typical paternity indices were 0.878. Furthermore, we found one microvariant allele at HLD93 (rs2307570) that has not been reported. We expect that these 30 loci of INDEL markers will be useful for forensic identification and paternity testing in the South Korean population.
Editor: Netherlands
Idioma: Inglês

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