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Catastrophic brain relapse in seronegative NMO after a single dose of natalizumab

Kitley, Joanna ; Evangelou, Nikos ; Küker, Wilhelm ; Jacob, Anu ; Leite, M. Isabel ; Palace, Jackie

Journal of the neurological sciences, 2014-04, Vol.339 (1), p.223-225 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Catastrophic brain relapse in seronegative NMO after a single dose of natalizumab
Autor: Kitley, Joanna ; Evangelou, Nikos ; Küker, Wilhelm ; Jacob, Anu ; Leite, M. Isabel ; Palace, Jackie
Assuntos: Adult ; Antibodies, Monoclonal, Humanized - adverse effects ; AQP4 ; Aquaporin-4 ; Brain - drug effects ; Brain - pathology ; Catastrophic Illness ; Devic's disease ; Female ; Humans ; Integrin alpha4 ; Natalizumab ; Neurology ; Neuromyelitis optica ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - drug therapy ; NMO
É parte de: Journal of the neurological sciences, 2014-04, Vol.339 (1), p.223-225
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Descrição: Abstract Natalizumab, an effective treatment for MS, has been shown to exacerbate neuromyelitis optica (NMO) with aquaporin-4 antibodies, but whether this is the case in antibody negative NMO and atypical MS/NMO spectrum disorder overlap syndromes is unknown. We describe a patient with a relapsing optico-spinal demyelinating syndrome, negative for aquaporin-4 antibodies, who experienced a catastrophic brain relapse shortly after a single dose of natalizumab, highlighting that MS immunomodulatory drugs may worsen demyelination in patients with seronegative NMO and atypical MS/NMO overlap syndromes even if they are aquaporin-4 antibody negative. We summarise the treatments considered safe and effective in NMO, and those with potential to exacerbate disease.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Catastrophic brain relapse in seronegative NMO after a single dose of natalizumab

Kitley, Joanna ; Evangelou, Nikos ; Küker, Wilhelm ; Jacob, Anu ; Leite, M. Isabel ; Palace, Jackie

Netherlands: Elsevier B.V

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